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Purified Aged Garlic Extract Modulates Allergic Airway Inflammation in Balb/c Mice
Aged Garlic extract Allergic airway inflammation IFNγ IgG1 IgE Murine model
2009/12/15
Garlic is known as a potent spice and a medicinal herb with broad therapeutic properties ranging from antibacterial to anticancer and anticoagulant. Our previous studies have shown some immunoregulato...
Enhanced Goblet Cell Hyperplasia in HDC Knockout Mice with Allergic Airway Inflammation
airway remodeling asthma Gob-5 MUC5AC TNF-α
2010/11/16
The number of eosinophils in BALF increased in both the sensitized wild-type mice and Hdc-/- mice with OVA inhalation. In addition, the numbers of alveolar macrophages and lymphocytes in BALF increase...
Attenuation of allergic airway inflammation and associated pulmonary functions by mycobacterial antigens is independent of IgE in a mouse model of asthma
airway hyperresponsiveness asthma Bacillus Calmette-Guérin eosinophils IgE Mycobacterium vaccae
2010/11/24
Neither BCG nor M. vaccae were able to attenuate the EAR, yet both were able to abrogate the parameters used to evaluate the LAR. Interestingly, in neither case were serum or OVA-specific IgE levels r...
Increased Levels of CTGF mRNA Expression in a Murine Model of Allergic Airway Inflammation
asthma collagen remodeling subepithelial fibrosis TGF-β
2010/11/19
Numbers of eosinophils and TGF-β1 concentration increased markedly in BALF on the 7th day and 14th day after inhalation challenge with OVA. Hydroxyproline content in lung tissue increased significantl...