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探讨鞘内注射Quinpirole(QNP)对骨癌痛大鼠镇痛及脊髓小胶质细胞活化的影响。方法 选取健康成年雄性SD大鼠60只通过胫骨骨髓腔内注射Walker256乳腺癌细胞液制备骨癌痛模型。将骨癌痛大鼠随机分为高剂量10μg/kg QNP(QNP-H)、低剂量5μg/kg QNP(QNP-L)及生理盐水(NS)3组,每组20只;QNP采用每日鞘内注射方式,注射体积为10μl。选取20只同周龄大鼠作对...
The effects of Quinpirole and Sulpiride on conflict responses in rat
Quinpirole Sulpiride conflict responses rat
2010/1/6
In this investigation wer studied the effect of dopaminergic system on the conflict behavior in rat, using vogel’s test. The related drugs were injected intraperitonealy (IP), and produced the followi...