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单一延长应激对Wistar大鼠海马Calcineurin表达的影响
创伤后应激障碍 单一延长应激 海马 Calcineurin
2020/11/12
探讨创伤后应激障碍模型-单一延长应激对Wistar大鼠海马钙调神经磷酸酶（Calcineurin,CaN）表达的影响。方法 将Wistar大鼠（n=30）随机分为单一延长应激组（n=15）和对照组（Control,n=15）。前者对大鼠实施国际公认的创伤后应激障碍（posttraumatic stress disorder，PTSD）动物模型方法-单一延长应激（Single-Prolonged S...
Penn/Wistar Study Finds ‘Sweet Spot’ Where Tissue Stiffness Drives Cancer’s Spread
Penn/Wistar Study Sweet Spot Tissue Stiffness Cancer’s Spread
2017/3/14
In order for cancer to spread, malignant cells must break away from a tumor and through the tough netting of extracellular matrix, or ECM, that surrounds it. To fit through the holes in this net, thos...
Decreased Activity in Neuropathic Pain Form and Gene Expression of Cyclin-Dependent Kinase5 and Glycogen Synthase Kinase-3 Beta in Soleus Muscle of Wistar Male Rats
Neuropathic Pain Soleus Muscle CDK5 Protein Kinase
2015/11/6
Background: The relationship between decreased activity/neuropathic pain and gene expression alterations in soleus muscle has remained elusive.
The effects of sildenafil ciltrate on the lateral geniculate body of adult Wistar rats (Rattus norvegicus)- A histological study
Sildenafil citrate lateral geniculate body decreased cellular population cellular hypertrophy vacuolations Wistar rats
2015/7/15
The histological effect of oral administration of sildenafil citrate (Viagra), commonly used as an aphrodisiac and for the treatment of erectile dysfunction on one of the visual relay centres namely t...
新生Wistar鼠母爱剥夺对其成鼠免疫功能的影响
新生Wistar鼠 母爱 成鼠免疫功能影响
2013/9/16
生命早期应激(early life stress, ELS), 即在成年前遭遇的负面事件, 如儿童早年经历的父母丧失和身体虐待, 可以引发重性抑郁症、受伤后应激障碍及精神分裂症等[1]。生命早期应激包括生命早期的环境因素及生命早期的生理和心理因素, 心理应激引起的生理反应包括机体心理应激时出现免疫系统的变化[2-3], 母爱剥夺属于生命早期应激。目前被认可的应用于啮齿类动物的生命早期应激是母爱剥夺...
探讨海分枝杆菌菌壁蛋白组特性及对Wistar大鼠致病免疫学特征，提高对海分枝杆菌致病机制的认识。方法 (1)将临床分离的海分枝杆菌经过培养7～10 d后，挑取培养的菌落，加入到0.9%氯化钠液体中，离心、PBS冲洗、超声破碎制备菌壁蛋白。将制备好的样品蛋白进行双向电泳，凝胶图像分析。(2)应用McFarland比浊法，制备菌液，估计所配制的细菌剂量浓度。选取雄性Wistar大鼠45只，数字随机法分...
不同浓度谷氨酸钠摄入对Wistar大鼠代谢及胰岛细胞凋亡的影响
谷氨酸钠 血糖 胰岛素 糖尿病
2013/11/12
探索不同浓度谷氨酸钠(MSG)摄入对大鼠代谢及胰岛细胞凋亡的影响。方法 将40只Wistar 大鼠随机分为对照组、MSG标准剂量组、MSG 4倍标准剂量组、MSG 8倍标准剂量组，每组10只。对照组给予生理盐水灌胃，MSG组给予自配的MSG溶液灌胃，每周空腹取尾静脉血1次，测血糖、甘油三酯、总胆固醇水平，于33周取颈动脉血测其血糖、胰岛素、甘油三酯、总胆固醇水平。结果 不同组间血糖水平差异...
Evaluation of Biochemical, Hematological and Histological Parameters in Non Diabetic and Diabetic Wistar Rats Fed with Monosodium Glutamate
MSG Glutamate Wistar Rat Diabetes
2013/1/29
The parenteral or oral administration of monosodium glutamate (MSG) has been reported to have a deleterious effect on the hypothalamic arcuate nucleus, which changes appetite control. This alteration ...
Pinealectomy and Exogenous Melatonin Regulate Anxiety-Like and Depressive-Like Behaviors in Male and Female Wistar Rats
Pinealectomy Melatonin Sex Dependent Anxiety Depression Behavioral Tests
2013/1/30
The main objective of this work was to 1) study the influence of endogenous melatonin (Mel) abolishment via pinealectomy and 2) explore exogenous Mel effect on anxiety-like and depressive-like behavio...
Synthesis and Influence of Two Quinoxalinone Derivatives on Anxiety- and Depressive-Like Responses in Wistar Rat
Depression Anxiety Quinoxalinone Derivatives Locomotor Activity Wistar Rats
2013/1/30
Two new quinoxalinone derivatives have been synthesized adopting the HONG method, and investigated for some neuropharmacological effects (anxiety- and depressive-like responses) in rats. The present e...
应用基因芯片技术研究雷公藤甲素对大鼠胸腺全基因表达谱的影响,从基因水平探讨雷公藤甲素引起免疫抑制毒性的潜在分子作用机制。方法 Wistar大鼠,连续28 d ig给予雷公藤甲素0.5和1.0 mg·kg-1以及环孢素A 20 mg·kg-1(阳性对照),进行T细胞依赖抗体反应检测、免疫器官组织病理学检查和胸腺组织基因芯片实验。结果 与溶媒对照组相比, 雷公藤甲素0.5和1.0 mg·kg-1组和环...
三聚氰胺和三聚氰胺类似物对Wistar大鼠经口染毒8周的毒性及预后
三聚氰胺 肾结石 肾功能衰竭
2013/10/29
观察连续8周ig给予三聚氰胺和三聚氰胺类似物对大鼠的毒性反应及预后情况。方法选择3周龄离乳的Wistar大鼠分别ig给予三聚氰胺300 mg·kg-1、三聚氰胺300 mg·kg-1+腺嘌呤100 mg·kg-1+氧嗪酸钾150 mg·kg-1和三聚氰胺300 mg·kg-1+三聚氰酸75 mg·kg-1,连续8周, 观察大鼠的一般体征,分别于给药2, 4, 6, 8周及恢复期1, 2, 3, 6...
目的比较BN大鼠和Wistar大鼠在Ⅰ型超敏反应中的敏感性，建立一种灵敏可靠的Ⅰ型超敏反应检测体系。方法 BN大鼠和Wistar大鼠分别隔天sc不同剂量的卵白蛋白（10，20和40 μg·kg-1），共5次，正常对照组sc给予生理盐水。首次注射后第21 天取血清, 用ELISA法测定血清总免疫球蛋白E（IgE）水平，通过被动皮肤过敏反应实验检测其特异性IgE水平；第22天检测激发后大鼠血压、血清...
The effect of dexamethasone in the pathogenesis of ligature-induced periodontal disease in Wistar rats
Alveolar bone loss Dexamethasone Periodontal diseases Rats
2009/10/20
The aim of this study was to evaluate, in rats, the role of the systemic use of dexamethasone in the pathogenesis of induced alveolar bone loss. In 26 female Wistar rats, ligatures were placed around ...