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Role of Ape1 and Base Excision Repair in the Radiation Response and Heat-radiosensitization of HeLa Cells
radiation hyperthermia DNA repair
2014/12/12
Background: The mechanism by which heat sensitizes mammalian cells to ionizing radiation remains to be elucidated. We determined whether base excision repair (BER) is involved in heat-radiosensitizati...
Protection of Human Lung Cells against Hyperoxia Using the DNA Base Excision Repair Genes hOgg1 and Fpg
oxygen toxicity DNA damage DNA repair
2014/12/12
Hyperoxia causes pulmonary toxicity in part by injuring alveolar epithelial cells. Previous studies have shown that toxic oxygen-derived species damage DNA and this damage is recognized and repaired b...
Altering DNA Base Excision Repair: Use of Nuclear and Mitochondrial-Targeted N-Methylpurine DNA Glycosylase to Sensitize Astroglia to Chemotherapeutic Agents
DNA repair astrocytes
2014/12/12
Primary astrocyte cultures were used to investigate the modulation of DNA repair as a tool for sensitizing astrocytes to genotoxic agents. Base excision repair (BER) is the principal mechanism by whic...
Small-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation
Ape1 inhibitor base excision repair biomarkers
2014/12/12
There has been a recent upsurge in the development of small-molecule inhibitors specific to DNA repair proteins or proteins peripherally involved in base excision repair and the DNA damage response. T...
Large Loop Excision of the Transformation Zone:An Outpatient Procedure
CIN LLETZ Outpatient Treatment Diagnosis
2009/6/29
A prospective, observational study was carried out to assess the efficacy of Large Loop Excision of the Transformation Zone (LLETZ) as an outpatient procedure during the first visit of patients with a...
Horner´s Syndrome Post-Excision of a Huge Cervical Sympathetic Chain Schwannoma
Schwannoma Horner´ s syndrome cervical sympathetic chain
2009/6/17
Schwannoma of the cervical sympathetic chain is a rare nerve tumor. These lesions typically present as an asymptomatic neck mass and are easily mistaken for a carotid body tumor during the initial wor...
Intraoperative Ethanol Treatment as an Adjuvant Therapy of Pterygium Excision
ethanol excision pterygium recurrence mitomycin
2009/4/20
Recurrence of pterygium is the main concern for ophthalmic surgeons after the excision of pterygium. To evaluate the efficacy and safety of ethanol treatment during pterygium excision in preventing t...
Hydatid disease of scapula and upper third of humerus treated by en bloc excision and fibular bone grafting
En bloc excision hydatid disease scapula and humerus
2008/11/27
35-year-old male patient presented with gradually increasing painful swelling of the right shoulder, which was incised and drained and wound persisted as a discharging sinus on the anterolateral aspec...
Do we really need high technology for excision of rhinophyma?
Acne rosacea rhinophyma tangential excision
2008/10/23
Rhinophyma is a rare disease that primarily affects Caucasian men in the fifth to seventh decades of life, characterized by a progressive thickening of nasal skin, which produces a disfiguring soft-ti...
Comparison between two methods of excision and primary closure of pilonidal sinus
Primary excision Pilonidal sinus Recurrence Wound infection Electrocautery
2015/9/9
Background: Controversy still exists about the best surgical method for the treatment of pilonidal sinus. The aim of this study was to compare two methods of excision and primary closure.