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Anticancer drug discovery:structures of KDM5 histone demethylase inhibitors
Anticancer drug KDM5 histone demethylase inhibitors
2016/8/1
When doctors hurl toxic death at cancer cells, often a few will survive and come back. A family of enzymes called KDM5 histone demethylases is emerging as important for this resilience, and drugs that...
Interaction between cellular retinoic acid-binding protein II and histone hypoacetylation in renal cell carcinoma
Retinoic acid Cellular retinoic acid-binding proteins Histone deacetylase Renal cell carcinoma
2015/7/28
Renal cell carcinoma is a rare but serious malignancy. Since a reduction in the level of retinoic acid receptor beta 2 (RARbeta2) expression in cancer cells due in part to histone hypoacetylation whic...
Effects of Histone Deacetylase Inhibitors on Vitamin D Activity in Human Breast Cancer Cells
Sulforaphane histone deacetylase inhibitors vitamin D receptor
2014/11/7
Breast cancer is one of the leading causes of death in women cancer cases worldwide. Cancer is the result of environmental and genetic factors that contribute to alterations in cellular control, proli...
HISTONE DEACETYLASE INHIBITORS TRICHOSTATIN A (TSA) AND SULFORAPHANE (SFN) MODULATE VITAMIN D RESPONSIVE CYP24 GENE EXPRESSION in 3T3-L1 PREADIPOCYTES
TRICHOSTATIN A (TSA) SULFORAPHANE (SFN), CYP24 3T3-L1 PREADIPOCYTES
2014/11/7
Vitamin D plays an important role in preserving healthy bones, and has additional roles in the body, including modulation of cell growth, differentiation, neuromuscular and immune function, and anti-i...
Are Lymphoblastoid Cell Lines Suitable to Study Increased SMN Gene Expression by Histone Deacetylase Inhibitors?
Spinal muscular atrophy survival motor neuron gene histone deacetylase inhibitors treatment
2009/6/16
Aim: In this preliminary study, we aimed to analyze the effect of sodium butyrate (NB) and phenylbutyrate (PB), belonging to the class of histone deacetylase (HDAC) inhibitors, on lymphoblastoid cell ...
Sperm Nuclear Histone to Protamine Ratio in Fertile and Infertile Men：Evidence of Heterogeneous Subpopulations of Spermatozoa in the Ejaculate
Sperm DNA male infertility
2008/12/24
Sperm protamine deficiency is observed in a subset of infertile men, suggesting that the relative histone to protamine ratio may be altered in the spermatozoa of these men. We measured the ratio of ...
In Vivo Effects of Histone-Deacetylase Inhibitor Trichostatin-A on Murine Spermatogenesis
Histone mouse protamine spermatogenesis
2008/12/22
The acetylation state of core histones is controlled by two classes of enzymes, histone acetyl transferases (HATs) and histone deacetylases (HDACs). HDAC inhibitors, such as trichostatin-A (TSA), ar...