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The mammalian metallothioneins (MT) are effectively induced in response to the various heavy metal ions. The inductions of these genes are mainly based on the transcriptional activation and the metal ...
Our object of this study was to investigate the effects of metallothionein, metal binding protein, on the change of the tissue distribution of essential metals by restraint stress. Wild-type and MT-nu...
Male Wistar rats were given cadmium by intraperitoneal (ip) injection (1mgCd/kg). Other male Wistar rats were given Cd by oral administration at a dose of 0, 1, 2, and 5 mgCd/kg/day. All rats were sla...
Increased metallothionein (MT)-IIA transcription is found in some cells with acquired resistance to cisplatin (CDDP). It is also known that mammalian MT is induced by copper. MT induction by TPA (12-O...
A metal chelator diethylenetriaminepentaacetic acid (DTPA) has been reported to inhibits replication of human cytomegalovirus (hCMV). In the investigation of the mechanism of DTPA-induced antiviral ef...
Methylmercury (MeHg) is a widespread environmental contaminant that causes reproductive dysfunction in men. Metallothioneins (MTs) are low-molecular-weight proteins that can bind heavy metals and pr...
Zinc levels in the prostate have been reported to be associated with the development and progression of malignant prostate cells. To investigate the reason why the zinc content decreases during th...
There is an increased risk of neural tube defects and axial skeletal malformations among infants born by mothers who had received Valproic acid...The aim of the present study is, if administration of ...

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