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Sho-seiryu-to Suppresses Histamine Signaling at the Transcriptional Level in TDI-Sensitized Nasal Allergy Model Rats
allergy gene expression histamine H1 receptors histamine signaling histidine decarboxylase Th2 cytokines
2010/11/16
SST significantly suppressed TDI-induced nasal allergy-like symptoms. TDI provocation showed a significant up-regulation of histamine H1 receptor (H1R) and histidine decarboxylase (HDC) gene expressio...
Analysis of Helper T Cell Responses to Cry j 1-Derived Peptides in Patients with Nasal Allergy: Candidate for Peptide-Based Immunotherapy of Japanese Cedar Pollinosis
Cry j 1 immunotherapy nasal allergy peptide Th response
2010/11/16
Our results suggest four Cry j 1-derived peptides (p61-80, p115-132, p206-225 and p337-353) may be considered to be the immunodominant T-cell epitopes of the Cry j 1 molecule, and can be useful for th...
Involvement of vascular endothelial growth factor in nasal obstruction in patients with nasal allergy
mast cells nasal allergy nasal antigen challenge test nasal obstruction vascular endothelial growth factor vascular permeability
2010/11/26
It has recently been shown that vascular endothelial growth factor (VEGF) enhances vascular permeability and that mast cells produce VEGF, suggesting the involvement of VEGF in allergic diseases. In t...