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Background: Interleukin (IL)-17-producing CD4+ T helper (Th17) cells thatare known by producing IL-17 have recently been defined as a unique subset of proinflammatory helper cells. IL-17 is an inflamm...
Background. Studies have implicated abnormalities in epigenetic gene regulation in schizophrenia. Presentation. We hypothesize that identifying abnormalities in chromatin structure and the epigenetic ...
Fludarabine is an inhibitor of DNA/RNA synthesis with antitumor activity on lymphoproliferative malignancies. We investigated the dose-dependent cytotoxic effects of the drug on human peripheral blood...
Aim: It is generally accepted that proinflammatory cytokines secreted by mononuclear cells are responsible for pancreatic beta (B) cell destruction in animal models of autoimmune type-1 diabetes melli...
Background:Atherosclerosis is a chronic inflammatory disease. We previously reported that a diet high in -linolenic acid (ALA) reduces lipid and inflammatory cardiovascular disease risk factors in hyp...
Interferon and interleukin (IL)-12 pro-duction increased significantly after 2 weeks treatment (P < 0.005 and P < 0.05, respectively), while IL-10 production decreased significantly after 2 and 4 we...
Suplatast tosilate significantly reduced TARC production by PBMCs. TARC mRNA was also suppressed in a concentration dependent manner. However, suplatast tosilate did not inhibit the expression of CCR-...
To investigate the relationship between local responsiveness and allergic symptoms, bronchial and nasal responsiveness were measured in the following four groups of subjects: (i) bronchial asthma pati...
The objective of the study was to determine the relation between the fatty acid composition of human peripheral blood mononuclear cell (PBMC) phospholipids and the functions of human immune cells.
Background: Tumor necrosis factor α (TNF-α) mediates inflammation. High TNF-α production has adverse effects during disease. Polymorphisms in the TNF-α and lymphotoxin α genes influence TNF-α producti...

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