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Effect of Shear Stress on RhoA Activities and Cytoskeletal Organization in Chondrocytes
Biomedical Engineering
2015/1/12
Mechanical force environment is a major factor that influences cellular homeostasis and remodeling. The prevailing wisdom in this field demonstrated that a threshold of mechanical forces or deformatio...
THE ROLE OF DAP-KINASE IN MODULATING VASCULAR ENDOTHELIAL CELL FUNCTION UNDER FLUID SHEAR STRESS
DAP-K Mechano-transduction Apoptosis Shear Atherosclerosis
2015/1/12
Atherosclerosis preferentially develops in vascular regions of low or disturbed flow and high spatial gradients. Endothelial cells that line the vessel walls actively participate in translating mechan...
The Response of Endothelial Cells to Fluid Shear Stress Using a Co-Culture Model of the Arterial Wall
Endothelial Cell Mechanical Stimulation Proliferation Smooth Muscle Cell Vascular Tissue Engineering
2010/1/7
An endothelial cell (EC) smooth muscle cell (SMC) co-culture
model of the arterial wall was used to study the effect of fluid shear
stress on EC behavior. This model, in addition to being a more rea...
Evaluation of the effect of stent strut profile on shear stress distribution using statistical moments
stent strut profile shear stress distribution statistical moments
2010/2/25
The strut shape found in the latest generations of stents are commonly dictated by manufacturing limitations. This research shows, however, that strut design can play a fundamental role in the improve...
Flow and wall shear stress in end-to-side and side-to-side anastomosis of venous coronary artery bypass grafts
Flow and wall shear stress venous coronary artery bypass grafts
2010/2/25
CFD analysis of venous CABG based on in-vivo CT datasets in patients was feasible producing qualitative and quantitative information on mass flow and WSS. Differences were found between the two types ...
Alterations in regional vascular geometry produced by theoretical stent implantation influence distributions of wall shear stress: analysis of a curved coronary artery using 3D computational fluid dynamics modeling
regional vascular geometry theoretical stent implantation a curved coronary artery 3D computational fluid dynamics modeling
2010/2/26
The current results predicting large spatial and temporal variations in WSS at specific locations in curved arterial 3D CFD simulations are consistent with clinically observed sites of restenosis. If ...
In-vivo coronary flow profiling based on biplane angiograms: influence of geometric simplifications on the three-dimensional reconstruction and wall shear stress calculation
In-vivo coronary flow profiling biplane angiograms
2010/2/26
We investigated the influence of two methods of lumen reconstruction, assuming circular versus elliptical cross-sections and using different resolutions for the cross-section reconstructions along the...
Axial stent strut angle influences wall shear stress after stent implantation: analysis using 3D computational fluid dynamics models of stent foreshortening
Axial stent strut angle 3D computational fluid dynamics models stent foreshortening
2010/2/26
The success of vascular stents in the restoration of blood flow is limited by restenosis. Recent data generated from computational fluid dynamics (CFD) models suggest that the vascular geometry create...
The relationship between wall shear stress distributions and intimal thickening in the human abdominal aorta
wall shear stress distributions intimal thickening the human abdominal aorta
2010/3/1
The histomorphometric analysis suggests that IT increases with age and that the distribution of intimal thickening changes with age. The lowest WSS in the flow model was found on the posterior wall in...