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The D-lemma: narrow-band UV type B radiation versus vitamin D supplementation versus sunlight for cardiovascular and immune health
narrow-band UV type B vitamin D immune health
2018/11/13
In this issue of the Journal, Ponda et al. (1) report on the role of vitamin D and narrow-band UV type B (UVB) irradiation on the blood lipid profile of healthy adults. They previously observed that t...
Introduction to workshop on iron screening and supplementation in iron-replete pregnant women and young children
iron pregnancy infancy young childhood iron screening iron supplementation
2018/11/21
The NIH Office of Dietary Supplements convened a public workshop on iron screening and supplementation in iron-replete pregnant women and young children in 2016 in Bethesda, Maryland. The starting poi...
DHA-rich n–3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study
fish oil DHA EPA DNA methylation LINE-1 Alzheimer disease
2018/11/20
Background: Dietary fish oils, rich in long-chain n–3 (ω-3) fatty acids (FAs) [e.g., docosahexaenoic acid (DHA, 22:6n–3) and eicosapentaenoic acid (EPA, 20:5n–3)], modulate inflammatory reactions thro...
Randomized, double-blind, placebo-controlled clinical trial of choline supplementation in school-aged children with fetal alcohol spectrum disorders
choline clinical trial fetal alcohol spectrum disorders fetal alcohol syndrome nutrition prenatal alcohol exposure supplementation
2018/12/19
Background: Prenatal alcohol exposure results in a broad range of cognitive and behavioral impairments. Because of the long-lasting problems that are associated with fetal alcohol spectrum disorders (...
Prenatal supplementation with DHA improves attention at 5 y of age: a randomized controlled trial
attention child development fatty acids prenatal supplementation omega-3 fatty acids preschool cognitive development
2018/12/14
Background: Docosahexanoic acid (DHA) is an important constituent of the brain. Evidence from well-designed intervention trials of the long-term benefits of increasing DHA intake during pregnancy has ...
Prenatal supplementation with DHA improves attention at 5 y of age: a randomized controlled trial
attention child development fatty acids prenatal supplementation omega-3 fatty acids preschool cognitive development
2018/12/18
Background: Docosahexanoic acid (DHA) is an important constituent of the brain. Evidence from well-designed intervention trials of the long-term benefits of increasing DHA intake during pregnancy has ...
Hypercalcemia, hypercalciuria, and kidney stones in long-term studies of vitamin D supplementation: a systematic review and meta-analysis
hypercalcemia hypercalciuria kidney stones randomized controlled trials vitamin D supplements
2018/12/18
Background: Vitamin D supplementation is increasingly being used in higher doses in randomized controlled trials (RCTs). However, adverse events from very large annual doses of vitamin D have been sho...
Research needs for assessing iodine intake, iodine status, and the effects of maternal iodine supplementation
clinical trials iodine deficiency iodine excess neurobehavioral development prenatal supplementation
2018/12/14
The Office of Dietary Supplements of the NIH convened 3 workshops on iodine nutrition in Rockville, Maryland, in 2014. The purpose of the current article is to summarize and briefly discuss a list of ...
Assessing infant cognitive development after prenatal iodine supplementation
Bayley scales brain systems cognitive behaviors infant neurodevelopment prenatal nutrition
2018/12/14
Little information is available on infant behavioral development outcomes of prenatal iodine supplementation in regions of mild to moderate iodine deficiency. Studies performed to date, all of which r...
Statistical design considerations applicable to clinical trials of iodine supplementation in pregnant women who may be mildly iodine deficient
clinical trials iodine supplementation outcomes measurement pregnancy statistical methods
2018/12/14
No large, randomized, placebo-controlled trial of iodine supplementation in pregnant women in a region of mild or moderate iodine deficiency has been completed in which a primary outcome measure was a...
A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA (ComparED) Study
DHA EPA inflammation men and women randomized controlled trial risk factors
2018/12/13
Background: To date, most studies on the anti-inflammatory effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in humans have used a mixture of the 2 fatty acids in various forms and...
Can long-chain PUFA supplementation during pregnancy influence later obesity risk?
long-chain PUFA upplementation pregnancy obesity risk
2018/11/30
Epigenetic regulation of adipose tissue by maternal diet during pregnancy could be the next primary prevention strategy to reduce obesity (1). It is well known that human phenotype can be influenced b...
The data do not seem to support a benefit to BCAA supplementation during periods of caloric restriction
BCAA supplementation caloric restriction
2016/5/16
J Int Soc Sports Nutr 13:1-015-0112-9, 2016 describe the efficacy of branched chain amino acid (BCAA) supplementation and resistance training for maintaining lean body mass during a calorie-restricted...
Acute Garcinia mangostana (mangosteen) supplementation does not alleviate physical fatigue during exercise:a randomized,double-blind,placebocontrolled,crossover trial
α-mangostin Hydroxycitric acid Exercise Exhaustion Muscle dynamic stiffness Blood biochemical
2016/5/16
Background:The purple mangosteen ( Garcinia mangostana), known as the "queen of fruit," is widely consumed and unique not only because of its outstanding appearance and flavor but also its remarkable ...
Acute and chronic safety and efficacy of dose dependent creatine nitrate supplementation and exercise performance
Creatine Nitrate Creatine nitrate Nutrition Supplementation Exercise performance
2016/5/16
Background:Creatine monohydrate (CrM) and nitrate are popular supplements for improving exercise performance; yet have not been investigated in combination. We performed two studies to determine the s...