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TGF-β Signaling May Play a Role in the Development of Goblet Cell Hyperplasia in a Mouse Model of Allergic Rhinitis
allergic rhinitis epithelial cells Smad TGF-β
2010/11/12
In the mouse model of allergic rhinitis, OVA challenge induced phosphorylation of Smad2 predominantly in epithelial cells in the nasal mucosa. In addition, the administration of an inhibitor of TGF-β ...
Antigen-Specific Immunotherapy against Allergic Rhinitis: The State of the Art
allergic rhinitis biomarker immunotherapy pollinosis regulatory T cell
2010/11/12
Allergic rhinitis is the most prevalent type I allergy in industrialized countries. Pollen scattering from trees or grasses often induces seasonal allergic rhinitis, which is known as pollinosis or ha...
The Relationship between Asthma and Allergic Rhinitis in the Iraqi Population
allergen allergic rhinitis allergy asthma
2010/11/16
Background: Recently, extensive research has established that epidemiologic and therapeutic links exist between allergic rhinitis and asthma. The objective of this study was to clarify this associatio...
A Single Center Study of Clinical and Paraclinical Aspects in Iranian Patients with Allergic Rhinitis
Allergic rhinitis Allergens Skin prick test Spirometry
2009/12/15
Allergic rhinitis (AR) is a common form of allergic disorder in Iran and rest of the world. This study was conducted to investigate the symptoms and paraclinical aspects of this allergy among Iranian ...
Peroxisome Proliferator-Activated Receptor γ Negatively Regulates Allergic Rhinitis in Mice
allergic rhinitis eosinophils murine model ovalbumin
2010/11/16
Background: Peroxisome proliferator-activated receptor γ(PPAR-γ) has been shown to play an important role in the control of inflammatory responses acting on macrophages, mast cells, T cells, and eosin...
Utility Weights for Allergic Rhinitis Based on a Community Survey with a Time Trade-off Technique in Japan
pollinosis Quality-Adjusted Life Years quality of life seasonal allergic rhinitis utility theory
2010/11/16
Background: Allergic rhinitis is not a fatal disease, but its symptoms deteriorate the quality of life. High morbidity raises a concern about its impact on health care resources. Utility weights, whic...
Absence of Nasal Blockage in a Japanese Cedar Pollen-Induced Allergic Rhinitis Model Mouse
allergic rhinitis animal model cedar pollen nasal blockage sneezing
2010/11/16
The serum Cry j 1-specific IgE level showed clear elevation only in the group sensitized by Cry j 1 + Al(OH)3 and then challenged by Cry j 1. No elevations were seen in the groups sensitized by pollen...
Effect of Local Nasal Immunotherapy on Nasal Blockage in Pollen-Induced Allergic Rhinitis of Guinea Pigs
allergic rhinitis animal model local nasal immunotherapy nasal blockage pollenosis
2010/11/17
Local nasal immunotherapy may be clinically useful for allergic nasal blockage associated with nasal hyperresponsiveness. The mechanisms responsible for this effectiveness might not be related to IgE ...
Amb a 1-immunostimulatory Oligodeoxynucleotide Conjugate Immunotherapy Increases CD4+CD25+ T Cells in the Nasal Mucosa of Subjects with Allergic Rhinitis
allergic rhinitis Amb a 1-immunostimulatory oligodeoxynucleotide immunotherapy ragweed-pollen allergy regulatory T cell
2010/11/17
The numbers of allergen-induced CD4+-, CD4+CD25+-, IL-10- and TGF-β-positive cells in the nasal mucosa after AIC immunization before the ragweed season did not differ between the two groups. Repeat ch...
Effect of Cry-consensus Peptide, a Novel Recombinant Peptide for Immunotherapy of Japanese Cedar Pollinosis, on an Experimental Allergic Rhinitis Model in B10.S Mice
allergic rhinitis Cry j 1 Cry j 2 Japanese cedar pollinosis T-cell epitope
2010/11/18
Cry-consensus peptide markedly inhibited Cry j 1-induced sneezes, eosinophil infiltration, and eosinophil peroxidase (EPO) activity in nasal tissue. Cry-consensus peptide inhibited the production of a...
Impact of Nasal Condition on Self-assessed Disease Control and Treatment Satisfaction in Patients with Asthma Complicated by Allergic Rhinitis
allergic rhinitis asthma questionnaire self-assessment treatment satisfaction
2010/11/18
Nasal condition is closely associated with self-assessed asthma condition and asthma treatment satisfaction. Controlling allergic rhinitis is critical to attain optimal management of asthma in patient...
Symptoms of Allergic Rhinitis in Women during Early Pregnancy Are Associated with Higher Prevalence of Allergic Rhinitis in Their Offspring
allergic rhinitis epigenetics offspring pregnancy symptoms
2010/11/18
Offspring whose mothers had any AR symptoms during early pregnancy showed a significantly higher adjusted odds ratio for the onset of AR in offspring than those whose mothers had no symptoms during pr...
An Evaluation of the Clinical Efficacy of Tomato Extract for Perennial Allergic Rhinitis
clinical efficacy eosinophils histamine release perennial allergic rhinitis tomato extract
2010/11/18
Background: Recently, some common foods in daily life have been found to have anti-allergic effects. We have reported that tomato extract (TE) could possibly inhibit histamine release and mouse ear-sw...
Dexamethasone Suppresses Histamine Synthesis by Repressing both Transcription and Activity of HDC in Allergic Rats
allergy dexamethasone HDC histamine rats
2010/11/19
In TDI-sensitized rats, nasal allergy-like behaviors such as sneezing and watery rhinorrhea were induced. Histamine content, HDC activity and HDC mRNA expression in nasal mucosa were also significantl...
Evaluation of FcεRI-binding serum IgE in patients with ocular allergic diseases
atopic keratoconjunctivitis ELISA FcεRI FcεRI-binding IgE seasonal allergic conjunctivitis
2010/11/29
We evaluated high-affinity receptor for IgE (FcεRI)-binding serum IgE in patients with atopic kerato- conjunctivitis (AKC; n = 31) and with seasonal allergic conjunctivitis (SAC; n = 13) by enzyme-lin...