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Leptin is a peptide that is strongly correlated with adiposity and is a potential determinant of obesity and its complications.
Since first reported less than a decade ago (1), leptin has been a topic of considerable study. The variation in serum or plasma leptin concentrations has been described according to sex, age, measu...
Although it is known that plasma leptin concentrations correlate with the amount of adipose tissue in the body, little information is available on the long-term effects on leptin concentrations of ...
Plasma leptin in humans is subject to both longand short-term regulation; it correlates with indexes of body fat that can only change slowly. However, short-term fasting causes large and rapid decr...
During the past 2 y the leptin field has continued to expand rapidly (from 600 to >2000 citations currently in the MEDLINE database), extending leptin biology into areas well beyond feeding behavior a...
Little is known about the effects of physical training on plasma leptin concentrations in children.
Leptin is known to be cleared by the kidney, a tissue with substantial leptin receptor mRNA expression; however, lung, liver, and muscle tissues also express leptin receptor messenger RNA and it is...
Background: Leptin is secreted by adipose tissue and decreases appetite. However, the role of leptin in the pathogenesis of hemodialysis (HD)-related malnutrition has not been fully evaluated.
This study investigated the effects of a long bout of aerobic exercise on hunger and energy intake and circulating levels of leptin and acylated ghrelin. Ten healthy male subjects undertook two, 4 h t...
We examined the leptin response and related hormones during and after two sub-maximal exercise protocols in trained and untrained subjects. During this study, plasma concentrations of leptin [Lep], in...
Leptin, a hormone synthesized by fat tissue had been noted to regulate energy balance and metabolism and thus to influence body weight. The influence of acute exercise and chronic exercise training on...
自1998年首次报道从鸡的肝组织中克隆获得“鸡Leptin基因”以来,鸡Leptin基因序列的正确性以及Leptin在家禽中的存在性就一直备受争议。虽然家禽Leptin受体的存在被广泛证实,但对其功能的研究也由于内源性Leptin的缺乏而受到限制。随着后基因组学研究时代的到来,使得在更大范围、更深层次上探寻鸟类Leptin基因的存在与否成为可能。2014年,3个独立的实验室先后报道了部分野生鸟类L...
Background: There is some evidence suggesting that leptin and its negative regulator, soluble-leptinreceptor (SLR) may be able to influence inflammatory and autoimmune processes.
探讨瘦素(leptin)对人脑胶质瘤U87MG细胞迁移及侵袭能力的影响及其机制。方法:Leptin处理U87MG细胞,采用细胞划痕实验检测U87MG细胞的迁移能力,Transwell实验检测U87MG细胞的侵袭能力,RT-PCR及Western blotting法检测U87MG细胞中MMP-2及MMP-9 mRNA和蛋白的表达。结果:Leptin明显促进U87MG细胞迁移能力\[(152.42±3...

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