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Oxidative stress is a putative factor in the pathogenesis of many human disorders of the central nervous system. Therefore, antioxidants such as vitamin E have become attractive as therapeutic agen...
In 1995, we described a new model for adiposity regulation. Since then, data regarding the biology of body weight regulation has accumulated at a remarkable rate and has both modified and strengthe...
Background: Ventilator-Associated Pneumonia (VAP) is the main cause of nosocomial infection at intensive care units (ICUs), which causes high mortality and morbidity. Objectives: The objective of the...
The aim of this study was to compare some depressors of the central nervous system combined with ketamine in order to find an adequate scombination for anaesthesia in mice, coupled with a simple, easy...
ObjectiveMethodsResultsConclusionSubstantial in vitro and in vivo evidence of neurotrophic and neuroprotective effects of lithium suggests that it may also have considerable potential for the treatmen...
Scientists at the Medical Research Council (MRC) have discovered that a gene called Sox9 plays a critical role in how stem cells behave and is crucial in the development of the central nervous system....
The aim of the present study was to determine if some naturally-occurring substitutions of amino acid residues of insulin could act differentially within the central nervous system (CNS) of neonatal c...
Two groups of divers were compressed to 300 msw (984 fsw) with heliox (n = 3) and trimix (n = 3). Neuropsychological/neurological testing was performed repeatedly during the compression and on reachin...
Two groups of divers were compressed to 500 msw with heliox (n = 3) and trimix (n = 3). They were followed with repeated neuropsychological and neurological tests during compression, at stable interme...
Central nervous system oxygen toxicity is currently the limiting factor in underwater swimming/diving operations using closed-circuit oxygen equipment. A dive series was conducted at the Navy Experime...
Blood glucose concentration was measured during continuous electrocorticographic (ECoG) recording in conscious rats exposed to 3 and 5 atmosphere absolute oxygen (ATA O2). The preconvulsive oxygen-ind...
Intermittent O2 breathing is a proven means of delaying pulmonary O2 toxicity during exposure to hyperbaric oxygen. The effect of an intermittent exposure in the pressure range toxic to the CNS was st...
Many aspects of central nervous system (CNS) decompression sickness (DCS) are poorly understood, including the temporal pattern of its presentation and the pathogenic mechanisms involved in the develo...
Imipenem, a very potent carbapenem derivative beta-lactam antibiotic, has recently found a major place in the treatment of antibiotic-resistant nosocomial infections. However, a convulsive side effect...
Hyperbaric oxygen (HBO2) is associated with a recognized risk for clinical central nervous system (CNS) toxicity. The risk for oxygen convulsions during routine hyperbaric treatment of most routine co...

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