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Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2
SARS-CoV-2 human ACE2 transgenic mouse COVID-19 pneumonia
2020/6/11
COVID-19 has spread worldwide since 2019 and is now a severe threat to public health. We previously identified the causative agent as a novel SARS-related coronavirus (SARS-CoV-2) that uses human angi...
Scientists have successfully regenerated cells in the retina of adult mice at the University of Washington School of Medicine in Seattle.Their results raise the hope that someday it may be possible to...
Exercise Training Reverses Extrapulmonary Impairments in Smoke-exposed Mice
DIAPHRAGM SKELETAL MUSCLE ENDOTHELIUM HIGH-INTENSITY INTERVAL TRAINING MITOCHONDRIAL FUNCTION COPD
2018/4/24
Purpose Cigarette smoking is the main risk factor for chronic obstructive pulmonary disease and emphysema. However, evidence on the extrapulmonary effects of smoke exposure that precede lung impairmen...
Exercise Attenuates High-Fat Diet–induced Disease Progression in 3xTg-AD Mice
INSULIN RESISTANCE EXERCISE TRAINING ALZHEIMER'S DISEASE COGNITIVE DECLINE
2018/4/24
Purpose Little is known regarding the therapeutic role of exercise against the risk of a high-fat diet (HFD) for Alzheimer's disease (AD) and AD-like cognitive deficits. This study aimed to investigat...
Oral administration of heat killed Tsukamurella inchonensis enhances immune responses and intestinal function in mice
immunomodulation delayed type hypersensitivity haemagglutination titre intestine villus histology liver spleen kidney
2016/12/8
We studied the effects of heat-killed Tsukamurella inchonensis on immune parameters and intestinal structure in mice. Mice were treated with three doses of bacteria (5 × 107, 1 × 108 and 2 × 108 CFU/m...
Ovariectomy increases squamous metaplasia of the uterine horns and survival of SENCAR mice fed a vitamin A–deficient diet
ovariectomy survival vitamin A deficiency
2016/6/1
Retinoic acid is necessary for the growth and differentiation
of organisms and exerts its molecular actions by
binding to specific nuclear receptors that belong to the thyroidsteroid
hormone recept...
Effect of Polysaccharides from Acanthopanax senticosus on Intestinal Mucosal Barrier of Escherichia coli Lipopolysaccharide Challenged Mice
Herbal Extract Intestinal Barrier Inflammation Epidermal Growth Factor Pro-inflammatory Cytokines Metabolism
2016/5/20
To investigate the role of polysaccharide from Acanthopanax senticosus (ASPS) in preventing lipopolysaccharide (LPS)-induced intestinal injury, 18 mice (at 5 wk of age) were assigned to three groups w...
< Previous Article Next Article > Endurance Training Attenuates Catabolic Signals Induced by TNF- in Muscle of Mice
EXERCISE INFLAMMATION UBIQUITIN-PROTEASOME PATHWAY
2017/4/13
Purpose: To determine whether endurance training attenuates the negative effects induced by an acute injection of tumor necrosis factor-α (TNF-α) in skeletal muscle of mice.
Methods: Trained (6 wk of...
The Effects of Aerobic Exercise on Plasma Adiponectin Level and Adiponectin-related Protein Expression in Myocardial Tissue of ApoE-/- Mice
Aerobic exercise, adiponectin, myocardial tissue
2016/2/23
Numerous reports have confirmed the effect of ApoE knockout
in the induction of cardiovascular diseases and the protective
effect of adiponectin against the progression of cardiovascular
disease...
Expression and Distribution of the Guanine Nucleotide-binding Protein Subunit Alpha-s in Mice Skin Tissues and Its Association with White and Black Coat Colors
Mice Guanine Nucleotide-binding Protein Subunit Alpha-s Coat Color Hair Follicle Skin Tissue Melanocyte
2016/11/10
Guanine nucleotide-binding protein subunit alpha-s (Gnαs) is a small subunit of the G protein-couple signaling pathway, which is involved in the formation of coat color. The expression level and distr...
Microcurrent Electrical Neuromuscular Stimulation Facilitates Regeneration of Injured Skeletal Muscle in Mice
Muscle injury regenerative potential
2015/8/28
Conservative therapies, mainly resting care for the damaged
muscle, are generally used as a treatment for skeletal muscle
injuries (such as muscle fragmentation). Several past studies
reported t...
Efflux of Creatine Kinase from Isolated Soleus Muscle Depends on Age, Sex and Type of Exercise in Mice
Skeletal muscle eccentric contractions muscle damage CK activity
2015/8/28
Elevated plasma creatine kinase (CK) activity is often used as an
indicator of exercise-induced muscle damage. Our aim was to
study effects of contraction type, sex and age on CK efflux from
iso...
Silk peptide treatment can improve the exercise performance of mice
Silk peptide Exercise performance Energy metabolism during exercise
2015/7/29
We randomized 36 7-week-old male ICR mice into 2 groups: the control (n = 18) and SP (n = 18) groups. All mice were trained by treadmill running 5 times per week for 2 weeks. S...
Proteomic analysis of plasma after branched chain enriched mixture supplementation in mice
Amino acids Proteome Dietary supplements
2015/7/27
Branched chain amino acid (BCAA) supplementation is a recently identified strategy to promote longevity in mice. A proteomic approach was used to identify proteins which are differentially expressed i...
RNA Synthesis in the Tracheal Epithelial Cells of Aging Mice as Revealed by Electron Microscopic Radioautography
RNA synthesis Macromolecular Microscopic radioautography 3H-uridine
2015/7/21
For the purpose of studying the aging changes of macromolecular synthesis in the tracheal epithelial cells of experimental animals, we studied 10 groups of aging mice during development and aging from...