搜索结果: 91-105 共查到“知识库 生物药物学”相关记录2074条 . 查询时间(2.078 秒)
鲍曼不动杆菌生物膜形成能力与生物膜相关基因及耐药性之间的关系
鲍曼不动杆菌 生物膜 耐药 生物膜相关基因
2014/10/17
探讨临床分离鲍曼不动杆菌菌株生物膜形成能力及生物膜相关基因的分布情况， 分析其与细菌耐药表型的关系。方法 采用前瞻性研究方法， 收集山东省成武县人民医院 2012 年 10 月至 2013 年 10月分离的 70 株鲍曼不动杆菌， 采用 96 孔聚苯乙烯板构建生物膜模型， 结晶紫染色法定性、 定量分析生物膜形成能力， 比较不同生物膜形成能力鲍曼不动杆菌对亚胺培南、 阿米卡星、 美罗培南、 头孢吡肟...
Impact of Abbreviated Lecture with Interactive Mini-cases vs Traditional Lecture on Student Performance in the Large Classroom
active learning individual readiness assessment test instructional design
2018/7/24
Objective. To compare the impact of 2 different teaching and learning methods on student mastery of learning objectives in a pharmacotherapy module in the large classroom setting.
Design. Two teachin...
不同产地草珊瑚优良种源筛选研究
草珊瑚 生物量 高效液相色谱法
2014/9/28
测定46个不同产地种源草珊瑚叶、茎的生物量以及活性成分落新妇苷、迷迭香酸、异嗪皮啶含量，以总量为考查指标，筛选优良种源。方法 样品来自福建三明三元吉口采育场草珊瑚种植栽培示范区3年生成熟草珊瑚，每个产地随机取20株，分叶与茎，晾干，称量，计算成每10株叶、茎干品重量作为生物量；含量测定采用HPLC。色谱柱：Ultimate C18(250 mm×4.6 mm，5 μm)；流动相A为乙腈-0.2%磷...
The Utility of Concept Maps to Facilitate Higher-Level Learning in a Large Classroom Setting
concept mapping critical thinking active learning
2018/7/13
Objective. To describe the utility of concept mapping in a cardiovascular therapeutics course within a large classroom setting.
Design. Students enrolled in a cardiovascular care therapeutics course ...
Evaluating the Potential Impact of Pharmacist Counseling on Medication Adherence Using a Simulation Activity
adherence counseling pharmacy simulation student
2018/7/13
Objective. To evaluate the impact of counseling in a simulated medication adherence activity.
Design. Students were randomized into 2 groups: patient medication monograph only (PMMO) and patient medi...
Long-term Effectiveness of Online Anaphylaxis Education for Pharmacists
e-learning knowledge evaluation Australasian Society of Clinical Immunology and Allergy
2018/7/10
Objective. To evaluate the long-term effectiveness of an Australasian Society of Clinical Immunology and Allergy (ASCIA) anaphylaxis e-learning program compared to lectures or no training.
Design. A ...
A Pharmaceutical Industry Elective Course on Practice Experience Selection and Fellowship Pursuit by Pharmacy Students
pharmacy, student education pharmaceutical industry
2018/7/10
Objective. To design and implement 2 pharmaceutical industry elective courses and assess their impact on students’ selection of advanced pharmacy practice experiences (APPEs) and pursuit of pharmaceut...
Implementation of an Integrated Longitudinal Curricular Activity for Graduating Pharmacy Students
NAPLEX, student learning curricular activity posters
2018/7/10
Objectives. To evaluate whether a novel integrated longitudinal curricular activity to prepare graduating doctor of pharmacy (PharmD) students for 2 comprehensive examinations was successful, and to a...
HPLC测定氯雷他定的含量及其有关物质
氯雷他定 有关物质 含量测定 高效液相色谱法
2014/9/3
建立高效液相色谱法测定氯雷他定含量及其5种有关物质。方法 采用Agilent TC-C18色谱柱(250 mm×4.6 mm，5 μm)，以乙腈-2%冰醋酸溶液为流动相，梯度洗脱，流速为1.0 mL·min?1，检测波长为276 nm。结果 氯雷他定及其5种杂质分离良好。氯雷他定、地洛他定、N-甲基地洛他定、三环酮、杂质F、杂质I分别在3.2~106.7，0.97~ 58.3，0.59~35.5，...
Modification of a Pharmacokinetics Course Design to Improve Student Performance
assessment pedagogy pharmacokinetics
2018/7/5
Objective. To determine if the addition of weekly quizzes or reducing the number of faculty members teaching improved third-year (P3) pharmacy students’ final grades in a clinical pharmacokinetics cou...
Simulated Drug Discovery Process to Conduct a Synoptic Assessment of Pharmacy Students
synoptic assessment drug discovery integrated learning simulation
2018/7/3
Objective. To implement and assess a task-based learning exercise that prompts pharmacy students to integrate their understanding of different disciplines.
Design. Master of pharmacy (MPharm degree) ...
ClC-3氯通道蛋白调控细胞增殖机制的研究进展
ClC-3 细胞增殖 氯离子通道
2014/11/12
ClC-3是电压门控性氯离子通道家族的成员，主要作为容积激活性氯通道通过调节容积激活性氯电 流[Cl,(vol)]，调节细胞体积，细胞膜电位等影响细胞增殖。近年的研究发现ClC-3也可通过调节有丝 分裂前凝集 (premitotic condensation，PMC) 过程，或维持细胞囊泡酸化和细胞内氧压，或作为调 控因子通过Akt-GSK-3β信号通路和CaMKII调节的信号通路等途径参与细胞增...
黄连解毒汤主要成分的体外抗炎作用研究
黄连素 汉黄芩素 抗炎 体外
2014/10/27
研究黄连解毒汤主要成分(黄连素、汉黄芩素)的体外抗炎作用及机制。方法 以小鼠J774A.1巨噬细胞为研究对象，分别设对照组，脂多糖(LPS)处理组，药物(不同剂量的黄连解毒汤主要成分)处理组；加入药物2 h后再加入LPS继续培养24 h，分别采用ELISA法检测关键炎症因子TNF-α、IL-6表达；逆转录聚合酶链反应(RT-PCR)检测细胞中COX-2 mRNA的水平；Western blot法测...
细胞色素P450与外源物的相互作用研究进展
细胞色素P450 外源物 药物代谢 抑制
2014/9/3
细胞色素P450酶是一种多功能酶系，它既参与外源物的生物转化，也与内源性物质的代谢有关，并且作为肝细胞药物代谢的主要酶系参与药物毒性的代谢灭活。由于P450酶结构、功能和基因调控的多样性，自其发现以来，该酶系的研究一直是毒理学研究中的一个热点。本文综述了P450与药物代谢相关的主要亚型及其与药物的相互作用，探讨了P450酶与外源物代谢之间的相互作用机制。