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Effects of tissue hydration on nanoscale structural morphology and mechanics of individual Type I collagen fibrils in the Brtl mouse model of Osteogenesis Imperfecta
AFM Ultrastructure Genotype/phenotype D-periodic spacing Modulus Energy
2014/11/6
Type I collagen is the most abundant protein in mammals, and is a vital part of the extracellular matrix for numerous tissues. Despite collagen’s importance, little is known about its nanoscale morpho...
Elevated Mechanical Loading When Young Provides Lifelong Benefits to Cortical Bone Properties in Female Rats Independent of a Surgically Induced Menopause
d mechanical loading exercise menopause bone properties
2014/11/6
Exercise that mechanically loads the skeleton is advocated when young to enhance lifelong bone health. Whether the skeletal benefits of elevated loading when young persist into adulthood and after men...
Applications of atomic force microscopy for the assessment of nanoscale morphological and mechanical properties of bone
Atomic Force Microscopy Scanning probe microscopy
2014/11/6
Scanning probe microscopy (SPM) has been in use for 30 years, and the form of SPM known as atomic force microscopy (AFM) has been around for 25 of those years. AFM has been used to produce high resolu...
In vivo reference point indentation reveals positive effects of raloxifene on mechanical properties following six months of treatment in skeletally mature beagle dogs
bone remodeling bone mechanics osteoporosis treatments indentation
2014/11/6
Raloxifene treatment has been shown previously to positively affect bone mechanical properties following one year of treatment in skeletally mature dogs. Reference point indentation (RPI) can be used ...
Nanoscale Structure of Type I Collagen Fibrils: Quantitative Measurement of D-spacing
Collagen fibril D-spacing 2D FFT AFM
2014/11/6
This article details a quantitative method to measure the D-periodic spacing of type I collagen fibrils using atomic force microscopy coupled with analysis using a two-dimensional fast fourier transfo...
Nanoscale Changes in Collagen are Reflected in Physical and Mechanical Properties of Bone at the Microscale in Diabetic Rats
Zucker diabetic Sprague-Dawley Atomic Force Microscopy Raman Spectroscopy Reference Point Indentation D-spacing Advanced Glycation End Products
2014/11/6
Diabetes detrimentally affects the musculoskeletal system by stiffening the collagen matrix due to increased advanced glycation end products (AGEs). In this study, tibiae and tendon from Zucker diabet...
Bone cell-independent benefits of raloxifene on the skeleton: A novel mechanism for improving bone material properties
Raloxifene mechanicaltesting toughness water
2014/11/6
Raloxifene is an FDA approved agent used to treat bone loss and decrease fracture risk. In clinical trials and animal studies, raloxifene reduces fracture risk and improves bone mechanical properties,...
Cortical Bone Mechanical Properties Are Altered in an Animal Model of Progressive Chronic Kidney Disease
chronic kidney disease whole bone mechanical properties
2014/11/6
Chronic kidney disease (CKD), which leads tocortical bone loss and increasedporosity,increases therisk of fracture. Animal models have confirmed that these changes compromise whole bone mechanical pro...
Physical Weight Loading Induces Expression of Tryptophan Hydroxylase 2 in the Brain Stem
mechanical loading serotonin
2014/11/6
Sustaining brain serotonin is essential in mental health. Physical activities can attenuate mental problems by enhancing serotonin signaling. However, such activity is not always possible in disabled ...
Multi-scale Analysis of Bone Chemistry, Morphology and Mechanics in the oim Model of Osteogenesis Imperfecta
Atomic force microscopy Raman Spectroscopy Reference Point Indentation MicroCT Crystallinity Modulus
2014/11/6
Osteogenesis imperfecta is a congenital disease commonly characterized by brittle bones and caused by mutations in the genes encoding Type I collagen, the single most abundant protein produced by the ...
Microcomputed Tomography Applications in Bone and Mineral Research
Bone CT Mineralization Vascularization BMD Modeling
2014/11/6
Microcomputed tomography (μCT) has evolved as a development of simple X-ray imaging into an indispensable technique used in both laboratory research and clinical diagnostics. Commercially available sy...
Multiscale analysis of morphology and mechanics in tail tendon from the ZDSD rat model of type 2 diabetes
AFM Tension Nanoscale Ultrastructure Modulus
2014/11/6
Type 2 diabetes (T2D) impacts multiple organ systems including the circulatory, renal, nervous and musculoskeletal systems. In collagen-based tissues, one mechanism that may be responsible for detrime...
重组人p66Shc腺病毒抑制HeLa细胞增殖的机制研究
p66Shc HeLa细胞 活性氧 p53
2014/10/27
探讨重组人p66Shc腺病毒（AdenoⅩ-p66Shc）对宫颈癌HeLa细胞增殖的抑制作用及机制。 方法 MTT法检测细胞活力，DCFH-DA荧光探针检测活性氧（ROS）生成；ELISA检测8-羟基脱氧鸟苷（8-OHdG）含量；Annexin Ⅴ-FITC/PI荧光染色检测细胞凋亡率；Western blot检测相关蛋白表达；免疫共沉淀检测p66Shc与p53之间相互作...
GC测定安立生坦原料药中6种有机溶剂残留
顶空进样法 毛细管气相色谱法 有机溶剂残留
2014/10/27
建立测定安立生坦原料药中可能残留的6种有机溶剂(甲醇、乙醚、二氯甲烷、乙酸乙酯、1,4-二氧六环、N,N-二甲基甲酰胺)含量的检测方法。方法 采用顶空气相色谱法，色谱柱为DB-624 毛细管柱(30.0 m×0.53 mm，3.00 μm)，氢火焰离子化检测器(FID)，进样口温度250 ℃，检测器温度300 ℃；载气为高纯氮气，恒压模式，压力2 psi；柱温为升温程序，50 ℃保持10 min，...