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Alteration of endogenous corticosteroids and catecholamines in allergen-induced eosinophilic inflammation in Brown Norway rats
airway inflammation asthma Brown Norway rat endogenous corticosteroid metabolic cage urinary catecholamine excretion urinary 11-hydroxycorticosteroid excretion
2010/11/29
Although various types of stress activate a pituitary adrenal response, the alteration of endogenous corticosteroids and catecholamines during asthma remains unclear. The aim of this study was to asse...
Specific IgE density assay: A new reverse enzyme allergosorbent test-based procedure for the quantitative detection of allergen-specific IgE
allergens IgE density radioallergosorbent test reverse enzyme allergosorbent test specific IgE total IgE
2010/11/29
A new method is described for the quantitative detection of IgE antibodies, based on IgE capture with a specific antibody, reaction with liquid-biotinylated allergens and biotinylated anti-IgE and imm...
Interleukin-4 is involved in allergen-induced airway eosinophilic inflammation and bronchial hyperresponsiveness independent of genetic background
bronchial hyperresponsiveness eosinophils IgE interleukin-4 mice
2010/11/26
The role of interleukin (IL)-4 in the development of allergen-induced airway inflammation and bronchial hyperresponsiveness (BHR) is still controversial. To investigate the role of IL-4 in the develop...
Purification of a novel allergen (SAP-1), which induces allergic asthma, from the red soft coral (Alcyonium gracillimum)
allergic protein bronchial asthma IgE occupational allergy purification red soft coral
2010/11/26
The red soft coral that is found around the spiny lobster represents a major allergen and many fishermen, especially those that catch the spiny lobster, suffer from allergic symptoms. Therefore, in th...
A case of milk allergy that presented anaphylaxis after cutaneous contact with allergen
anaphylaxis atopic dermatitis cutaneous contact milk allergy
2010/11/25
Milk allergy in a 1-year and 8-month-old boy is reported. At 1 year and 1 month of age, the patient presented with anaphylaxis, including erythema, which was initially localized to the contact site of...
Sequential IgE epitope analysis of a birch pollen allergen (Bet v1) and an apple allergen (Mal d1)
apple Bet v1 birch immunotherapy Mal d1 sequential IgE epitope
2010/11/25
Cross-reactivity in IgE epitopes and T cell epitopes has been reported between major birch pollen allergen (Bet v1) and major apple allergen (Mal d1). To treat people with birch pollinosis complicated...
Effect of modified immunotherapy with an allergen-pullulan conjugate in patients with Japanese cedar pollinosis
eosinophil immunotherapy Japanese cedar pollinossis mast cell seasonal allergic rhinitis Th1 cytokine Th2 cytokine
2010/11/25
Immunologic mechanisms of allergen immunotherapy are still incompletely understood. Immunotherapy of a higher maximum tolerance dose with reduced risks of systemic reactions, such as anaphylaxis, need...
Allergen immunotherapy: Current and new therapeutic strategies
allergen IgE immunotherapy T cell
2010/11/24
Allergen-specific immunotherapy (SIT) involves the administration of gradually increasing amounts of an allergen extract to reduce clinical symptoms of allergy. Well-controlled clinical trials have de...
Immunologic determination of the major allergen, Cry j 1, in Cryptomeria japonica pollen of 117 clones in Toyama prefecture: Some implications for further forestry research in pollinosis prevention
Cry j 1 Cryptomeria japonica D. Don environmental factor genotype variation Japanese cedar pollinosis
2010/11/24
Background: A number of recent studies have clarified the characteristics of major allergens of Cryptomeria japonica, such as the locality, molecular weights of Cry j 1 and Cry j 2 and cross-reactivit...
Anaphylaxis caused by the ingestion of cultivated mushroom (Agaricus bisporus): Identification of allergen as mannitol
Agaricus bisporus anaphylaxis cultivated mushroom food allergy low molecular weight allergen mannitol
2010/11/24
The SPT with mushroom extract was strongly positive; however, allergen-specific IgE could not be detected by enzyme-linked immunosorbent assay. The SPT was also positive with cooked, steamed or dried ...
Effect of cysteine mutagenesis on human IgE reactivity of recombinant forms of the major rye grass pollen allergen Lol p 1
allergy grass pollen Lol p 1 mutagenesis rye grass
2010/11/24
Background: Hypersensitivity to the group 1 grass pollen allergens is a significant causative factor in the onset of symptoms for hay fever sufferers. To better understand the IgE reactivity of the gr...
A Photo-immobilized Allergen Microarray for Screening of Allergen-specific IgE
allergen microarray allergen-specific IgE allergy diagnosis chemiluminescence photo-immobilization
2010/11/22
Background: We developed an in vitro system to diagnose allergy using an allergen microarray and photo-immobilization technique. Photo-immobilization is useful for preparing the allergen microarray be...
Survey of Food and Airborne Allergen-specific IgE Levels in a General Population of 3-year-old Japanese Children
3-year-old children antigen-specific IgE pollen serum total IgE
2010/11/22
The mean total IgE level of all subjects was 34.7 IU/ml, while that for the Kanto and Asahikawa areas was 44.7 and 22.5 IU/ml, respectively. Twenty six percent of the 612 children were judged positive...
Evaluation of Six Years Allergen Immunotherapy in Allergic Rhinitis and Allergic Asthma
Allergic rhinitis Asthma Immunotherapy
2010/2/8
Allergen immunotherapy involves the administration of gradually increasing quantities of specific allergens to patients with IgE-mediated conditions until a dose is reached that is effective in reduci...
Future of allergen-specific immunotherapy.