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The Association between Sporadic Alzheimer’s Disease and the Human ABCA1 and APOE Gene Polymorphisms in Iranian Population
Alzheimer’s disease Genetic association Apolipoprotein E Polymorphism ATP-binding cassette transporter A1 Iran
2015/9/23
Background: Apolipoprotein E (APOE), which its ε4 allele has been reported as a risk factor in late onset Alzheimer’s disease (AD), is the main cholesterol carrier in the brain. ATP-binding cassette t...
Missense and Nonsense Mutations of P53 Gene in Patients with Colorectal Adenocarcinoma in Isfahan,Central Iran
Missense Nonsense Mutations Patients Colorectal Adenocarcinoma Isfahan Central Iran
2015/9/22
The colorectal cancer is the forth prevalent cancer worldwide. The incidence and mortality of colorectal cancer (CRC) in men and women has been estimated more than 1.233 million cases and nearly 61000...
Association between MDR1 C3435T Gene Polymorphism and Acute Lymphoblastic Leukemia (ALL) in Iranian Population
P-glycoprotein MDR1 Acute lymphoblastic leukemia C3435T polymorphism
2015/9/21
Background: P-glycoprotein (P-gp), an ATP-dependent efflux pump, is a membrane protein encoded by MDR1 gene. P-gp has an important role in protection of the cell against xenobiotics and toxic compound...
Interleukin-12 and Tumor Necrosis Factor-Β Gene Polymorphisms as Genetic Susceptibility Factors for Brucellosis in Iranian Patients
Brucella Genetic polymorphisms Interleukin-12 Tumor necrosis factor-β Iran
2015/9/21
cMethods: One hundred and ninety-six patients with brucellosis and 81 healthy farmers (controls) who owned infected animals and consumed their contaminated dairy products were included in this study. ...
Heme Oxigenase 2 Gene Polymorphisms as Genetic Risk Factor in Atherosclerosis in Iranian Patients
Atherosclerosis Heme oxigenase 2 Coronary artery disease Iran
2015/9/21
Background: Heme oxygenase 2 (HMOX2) is an important antioxidative stress enzyme found in the endothelial cells of blood vessels and adventitial nerves. This enzyme in collaboration with heme oxygenas...
Gene links lower birth weight and type 2 diabetes（图）
Gene links birth weight type 2 diabetes
2010/4/29
Two gene regions that influence a baby’s weight at birth have been identified by a large international team of researchers, including scientists from Oxford University. One of the genes is also associ...
Association between Endothelial Selectin (E-Selectin) Gene Polymorphisms and E-Selectin Level with Visceral Leishmaniais, in an ARMS-PCR Based Study
Soluble E-selectin Gene Polymorphism Visceral Leishmaniasis Human ARMS-PCR Ser128Arg 554Leu/Phe
2009/12/18
Background: In the visceral leishmaniasis (VL), parasites reside in reticuluendothelial system, mainly in macrophages. Endothelial Selectin (E-selectin) might play an important role in leukocyte-endot...
Molecular genetic,diagnosis,prevention and gene therapy in prostatic cancer: review article
Molecular genetic diagnosis prevention gene therapy prostate cancer
2009/12/15
The prostate is a small gland located below the bladder and upper part of the urethra. In developed countries prostate cancer is the second common cancer (after skin cancer), and also the second leadi...
Collection of multiple processes that increase the chronological age of an organism leading to death is defined as aging, and even though important, it is poorly understood. Recent research has shown ...
Detection of Aflr Gene and Toxigenicity of Aspergillus flavus Group Isolated from Patients with Fungal Sinusitis
Detection Aflr Gene Toxigenicity Aspergillus flavus Group Isolated Patients Fungal Sinusitis
2009/12/7
Background: Aspergillus flavus is the second most important Aspergillus species causing human infections particularly fungal sinusitis. Since little is known about aflatoxin producing abilit...
Genomic signature and toxicogenomics comparison of polycationic gene delivery nanosystems in human alveolar epithelial A549 cells
Gene Delivery Nanosystem Gene Expression Genocompatibility Microarray Toxicogenomics
2009/12/3
Background and the purpose of the study: Of the gene delivery systems, non-viral polycationic gene delivery nanosystems have been alternatively exploited as a relatively safe delivery reagents compare...
Association of Methylenetetrahydrofolate Reductase gene Polymorphism (C677T) with Metabolic Syndrome in an Iranian Population: Tehran Homocysteine Survey
MTHFR Metabolic syndrome Population
2009/11/26
Background: The association of MTHFR and metabolic syndrome (MS) has been shown in special groups of diabetic and schizophrenic subjects, but no single study has investigated this relation in metaboli...
Deletion and Testicular Expression of DAZ (Deleted in Azoospermia) Gene in Patients with Non-Obstructive Azoospermia
Infertility Deleted in Azoospermia Gene Y Chromosome Azoospermia Iran
2009/11/26
Background: Deletions of the DAZ (deleted in azoospermia) genes within the human Y chromosome's AZFc region are the most common cause of spermatogenesis failure. These deletions are usually assessed b...
emm Gene Polymorphism among Streptococcus pyogenes Isolated from Throat Culture
Streptococcus pyogenes PCR- RFLP emm gene Pharyngitis
2009/11/26
DNA sequencing is the most conclusive method for emm (M protein gene) typing of Streptococcus pyogenes. This method is not a feasible approach in developing countries where streptococcal infection is ...
Variation in the visfatin gene may alter the required dosage of oral antidiabetic agents in type 2 diabetic patients
Visfatin Genotype Antidiabetic agents HOMA QUICKI Type 2 diabetes
2009/11/24
Background: Treatment of diabetes with oral antidiabetic agents is accompanied by considerable variability in pharmacokinetics and clinical efficacy. Genetic factors may contribute to individual diffe...