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No Association of Polymorphisms in the 5' Region of the CD14 Gene and Food Allergy in a Japanese Population
5' region CD14 food allergy gene polymorphism
2010/11/18
Background: The gene encoding CD14 is a positional candidate gene for allergic diseases as it is localized on chromosome 5q31, a region that is linked to atopy-related phenotypes.
Although it has bee...
Congratulation to Margaret Chan Familial and Sporadic GJB2-Related Deafness in Iran: Review of Gene Mutations
Connexin 26 Deafness Autosomal recessive non syndromic hearing loss Iran
2010/4/6
Background: Mutations in the GJB2 gene encoding connexin 26 protein, are the main cause for autosomal recessive and sporadic non syndromic hearing loss in many populations. Here, we have taken togethe...
Association between the Polymorphisms of IL-4 Gene Promoter (-590C>T),IL-13 Coding Region (R130Q) and IL-16 Gene Promoter (-295T>C) and Allergic Asthma
Allergic asthma Interleukin-4 Interleukin-13 Interleukin-16
2010/4/2
Allergic asthma is a multifactorial disease, influenced by genetic and environmental factors. Recent family-based studies have revealed evidence for linkage of human chromosomes 5q31-33, 12q15-24, 11q...
Molecular Characterization of GTP Binding Protein Gene in Dermatophyte Pathogen Trichophyton rubrum
Dermatophyte Trichophyton rubrum Fungal RNA Fungal DNA Nucleic acid sequencing
2010/2/5
Trichophyton rubrum (T. rubrum) is an anthropophilic dermatophyte that is distributed worldwide and causes common cutaneous disease such as mycosis. Although several properties of this fungus have bee...
Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T Polymorphism Is Associated with Coronary Atherosclerosis Disease in a Sample of Iranian Patients
MTHFR CAD Folate Folic acid Homocysteine
2010/4/6
Background: Several studies showed that elevated plasma homocysteine level is a risk factor for coronary artery disease (CAD). A common polymorphism C677T of methylenetetrahydrofolate reductase (MTHFR...
Analysis of Plasmodium vivax Merozoite Surface Protein-1 Gene Sequences
Malaria Plasmodium vivax Merozoite surface antigen (MSP-1) Belem allel (Bel) Iran
2010/2/3
The emergence of Plasmodium vivax in Dashte Moghan in northwestern Iran has become a major concern for Iranian's health officials. Knowledge of genetic make up of the P. vivax populations in this area...
SSU- rRNA Gene Analysis of Cryptosporidium spp. in HIV Positive and Negative Patients
Cryptosporidium SSU-rRNA gene HIV Iran
2010/2/8
Cryptosporidium is an apicomplexan parasite of humans and a wild range of domestic as well as wild animals. An 833-bp fragment of the 18S-rRNA gene was used to identify Cryptosporidium spp. recovered ...
Association between the Polymorphism of TGF-β1 Gene Promoter (-509C>T) and Idiopathic Chronic Urticaria
Polymorphism TGF-1 gene Urticaria
2010/2/1
Idiopathic Chronic Urticaria (ICU), the most common form (70-80%) of chronic urticaria is supposed to have immune basis causes. It is speculated that the promoter polymorphism of TGF-β1 gene may be in...
Gene Expression Profiling of Human Mast Cell Subtypes: An In Silico Study
carboxypeptidase chymase human mast cells microarray transcriptome
2010/11/18
The MC lineage seems to be far from the granulocyte lineages including basophils. CMA1-high MCs (MCTC) and CMA1-low MCs (MCT) can be regarded as differentiated MC subtypes. As such, importance of data...
Genetic Diversity in the Circumsporozoite Protein Gene of Plasmodium falciparum from Major Endemic Regions of Iran
Circumsporozoite protein Plasmodium falciparum Malaria Iran
2010/2/8
Circumsporozoite protein (CSP) is one of the stage specific antigens, which is used for the development of vaccines and to investigate the genetic diversity in Plasmodium falciparum malaria parasite. ...
Association of the RIP2 Gene with Childhood Atopic Asthma
asthma linkage disequilibrium receptor-interacting protein 2 (RIP2) single nucleotide polymorphism Toll-like receptors
2010/11/18
A total of 31 variants were identified and none of the alleles or haplotypes of RIP2 were associated with asthma susceptibility. In the case-only study, an association between an RIP2 promoter polymor...
Mutation Analysis of CFTR Gene in 70 Iranian Cystic Fibrosis Patients
Cystic fibrosis Cystic fibrosis transmembrane conductance regulator Mutations Iran Single-stranded conformational polymorphism
2010/2/3
Cystic fibrosis (CF) is the most common inherited disorder in Caucasian populations, with over 1400 cystic fibrosis transmembrane conductance regulator (CFTR) mutations. The type of mutations and thei...
Comparison of local cytokine gene expression and the distribution of eosinophils and CD4-positive cell subsets in the paranasal sinus mucosa between atopic and non-atopic subjects
allergic rhinitis CCR4 CD4 chronic sinusitis CXCR3 cytokines eosinophils
2010/11/22
These results indicate that high expression of Th2-type cytokines concomitant with the infiltration of a predominant number of CD4+ cells and their Th2 subsets play a role in the pathogenesis of eosin...
Lack of Association between Atopic Dermatitis and -401A/G Polymorphism in the Promoter Region of the RANTES Gene in Japanese
atopic dermatitis IgE polymorphism RANTES
2010/11/22
Background: Regulated on activation, normal T expressed and secreted (RANTES) has been known to be deeply involved in the pathophysiology of atopic dermatitis (AD). To examine whether a -401A/G polymo...
Molecular Characterization of a 70 kDa Heat Shock Protein (HSP70) Gene in Entamoeba dispar
Amebiasis HSP70 Entamoeba dispar DNA
2010/2/3
Amebiasis caused by Entamoeba histolytica is still mentioned as one of the major health problems in tropical and subtropical areas. E. histolytica has recently been redescribed as two distinct species...