搜索结果: 31-45 共查到“临床医学 DNA”相关记录183条 . 查询时间(0.312 秒)
北京大学生物动态光学成像中心/北京未来基因诊断高精尖创新中心/生命科学联合中心/工学院黄岩谊教授课题组日前在DNA测序方法的研究上取得重要突破。该团队在此前谢晓亮教授首创的荧光发生测序技术基础上发展了一种全新概念的测序方法——纠错编码（简称ECC）测序法。ECC测序法采取一种独特的边合成边测序（SBS）策略，利用多轮测序过程中产生的简并序列间的信息冗余，大幅度增加了测序精度。该进展于2017年11...
DHA-rich n–3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study
fish oil DHA EPA DNA methylation LINE-1 Alzheimer disease
2018/11/20
Background: Dietary fish oils, rich in long-chain n–3 (ω-3) fatty acids (FAs) [e.g., docosahexaenoic acid (DHA, 22:6n–3) and eicosapentaenoic acid (EPA, 20:5n–3)], modulate inflammatory reactions thro...
第十六届共济失调性毛细血管扩张症研讨会（ATW-2015）暨第六届DNA损伤应答与人类疾病国际研讨会（isDDRHD-2015）在首都师范大学举行（图）
第十六届 研讨会 毛细血管
2015/11/12
2015年10月11日—14日，由我校DNA损伤应答北京市重点实验室、北京细胞生物学会和中国细胞生物学会信号转导分会共同主办的第十六届共济失调性毛细血管扩张症研讨会（Ataxia-Telangiectasia Workshop, ATW-2015）暨第六届DNA损伤应答与人类疾病国际研讨会（international symposium on DNA Damage & Human Diseases...
Evaluation of In Vivo Transfection Efficiency of Eudragit Coated Nanoparticles of Chitosan-DNA: A pH-sensitive System Prepared for Oral DNA Delivery
Gene Therapy Delivery of DNA Nanoparticles
2015/10/22
Background: Success of any gene therapy protocol relies mostly on using an efficient carrier to direct nucleic acid to the place of action. The system should also have transfection ability at release ...
第十六届共济失调性毛细血管扩张症研讨会（ATW-2015）暨第六届DNA损伤应答与人类疾病国际研讨会（isDDRHD-2015）在北京举行（图）
第十六届 共济失调性毛细血管扩张症 研讨会 第六届 DNA损伤应答与人类疾病 国际研讨会 北京
2015/11/6
由首都师范大学DNA损伤应答北京市重点实验室、北京细胞生物学会和中国细胞生物学学会信号转导分会共同主办的第十六届共济失调性毛细血管扩张症研讨会（Ataxia-Telangiectasia Workshop, ATW-2015）暨第六届DNA损伤应答与人类疾病国际研讨会（international symposium on DNA Damage & Human Diseases, isDDRHD-2...
Since the turn of the millennium, DNA testing has helped with establishing the sizes of biological descent families within surnames. Some surnames have a dominant family: their remaining populations c...
Role of the Multifunctional DNA Repair and Redox Signaling Protein Ape1/Ref-1 in Cancer and Endothelial Cells: Small-Molecule Inhibition of the Redox Function of Ape1
APE1/Ref-1 redox signaling cancer
2014/12/12
The DNA base excision-repair pathway is responsible for the repair of DNA damage caused by oxidation/alkylation and protects cells against the effects of endogenous and exogenous agents. Removal of th...
Protection of Human Lung Cells against Hyperoxia Using the DNA Base Excision Repair Genes hOgg1 and Fpg
oxygen toxicity DNA damage DNA repair
2014/12/12
Hyperoxia causes pulmonary toxicity in part by injuring alveolar epithelial cells. Previous studies have shown that toxic oxygen-derived species damage DNA and this damage is recognized and repaired b...
Altering DNA Base Excision Repair: Use of Nuclear and Mitochondrial-Targeted N-Methylpurine DNA Glycosylase to Sensitize Astroglia to Chemotherapeutic Agents
DNA repair astrocytes
2014/12/12
Primary astrocyte cultures were used to investigate the modulation of DNA repair as a tool for sensitizing astrocytes to genotoxic agents. Base excision repair (BER) is the principal mechanism by whic...
DNA Repair Proteins as Molecular Targets for Cancer Therapeutics
DNA repair cancer therapeutics
2014/12/12
Cancer therapeutics include an ever-increasing array of tools at the disposal of clinicians in their treatment of this disease. However, cancer is a tough opponent in this battle and current treatment...
Conversion of the Bifunctional 8-oxoguanine/β-δ AP DNA Repair Activities of Drosophila Ribosomal Protein S3 into the Human S3 Monofunctional β- elimination Catalyst Through a Single Amino Acid Change
DNA repair drosophila ribosomal protein s3
2014/12/12
The Drosophila S3 ribosomal protein has important roles in both protein translation and DNA repair. In regards to the latter activity, it has been shown that S3 contains vigorous N-glycosylase activit...
A novel fluorometric oligonucleotide assay to measure O 6-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase
APE1/Ref-1 DNA repair status
2014/12/12
DNA repair status plays a major role in mutagenesis, carcinogenesis and resistance to genotoxic agents. Because DNA repair processes involve multiple enzymatic steps, understanding cellular DNA repair...
Conditional Targeting of the DNA Repair Enzyme hOGG1 into Mitochondria
DNA repair mitochondria
2014/12/12
Oxidative damage to mitochondrial DNA (mtDNA) has been suggested to be a key factor in the etiologies of many diseases and in the normal process of aging. Although the presence of a repair system to r...
Knockdown of the DNA repair and redox signaling protein Ape1/ Ref-1 blocks ovarian cancer cell and tumor growth
base excision repair APE1/Ref-1 ovarian cancer
2014/12/12
Apurinic endonuclease 1/redox effector factor-1 (Ape1/Ref-1 or Ape1) is an essential protein with two distinct functions. It is a DNA repair enzyme in the base excision repair (BER) pathway and a redu...
N-methylpurine DNA glycosylase overexpression increases alkylation sensitivity by rapidly removing non-toxic 7-methylguanine adducts
N-methylpurine DNA glycosylase alkylating agents cancer therapeutics
2014/12/12
Previous studies indicate that overexpression of N-methylpurine DNA glycosylase (MPG) dramatically sensitizes cells to alkylating agent-induced cytotoxicity. We recently demonstrated that this sensiti...