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Amphiregulin is Not Essential for Induction of Contact Hypersensitivity
amphiregulin contact dermatitis EGF mast cells Th2 cell/cytokine
2010/11/12
Background: Amphiregulin (AR) is expressed in Th2 cells, rather than Th1 cells, and plays an important role in Th2 cell/cytokine-mediated host defense against nematodes. We also found earlier that AR ...
The Inflammasome, an Innate Immunity Guardian, Participates in Skin Urticarial Reactions and Contact Hypersensitivity
contact hypersensitivity IL-1β inflammasome NLRP3 urticaria
2010/11/12
Urticarial rash, one of the clinical manifestations characteristic of cryopyrin-associated periodic syndrome (CAPS), is caused by a mutation in the gene encoding for NLRP3 (nucleotide-binding oligomer...
Effect of Am-80, a novel retinoid derivative, on contact hypersensitivity caused by repeated applications of hapten in mice
2, 4-dinitrofluorobenzene Am-80 contact dermatitis cytokine retinoid
2010/11/25
Some retinoids show an anti-inflammatory action through regulation of transcription of various genes. In the present study, the inhibitory effect of 4-((5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphth...
Staphylococcus aureus colonization in contact hypersensitivity induces a shift in cutaneous cytokine milieu from a Th1- to a Th2-type profile
atopic dermatitis Staphylococcus aureus Th1 cells Th2 cells
2010/11/24
In TNCB-challenged lesions inoculated with S. aureus, the levels of IL-2 mRNA decreased; in contrast, mRNA levels of IL-4 and IL-5 were upregulated. In mite antigen-challenged lesions, IL-4 and IL-5 m...