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Genetic Variability of the High-affinity IgE Receptor α Subunit (FcεRIα) is Related to Total Serum IgE levels in Allergic Subjects
allergy FCER1A FcεRIα genetic polymorphism IgE omalizumab
2010/11/18
Known susceptibility genes to atopy and asthma have been identified by linkage or associations with clinical phenotypes, including total serum IgE levels. IgE-mediated sensitivity reactions require a ...
Recombinant soluble form of the high-affinity IgE receptor α subunit and anti-IgE antibody inhibit IgE synthesis by IgE-expressing B cells through distinct pathways
apoptosis divalent recognition IgE-binding agents IgE-expressing B cells interleukin-6 monovalent recognition
2010/11/24
Background: Both a recombinant soluble form of the high-affinity IgE receptor α subunit (rsFcεRIα) and anti-IgE antibody have been shown to be involved in the regulation of IgE synthesis. However, the...
The High Affinity IgE Receptor (FcεRI) as a Target for Anti-allergic Agents
FcεRI gene expression humanized anti-FcεRI α chain antibody IgE soluble α
2010/11/19
Prevention of the effector cell activation via high affinity IgE receptor (FcεRI) is thought to be a straightforward strategy for suppressing the allergic reaction. Among the numerous methods to preve...