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CCR5 on the NK Cells and its Ligand (RANTES) Expressions are Disrupted in South-Eastern Iranian Patients With Chronic Hepatitis B Infection
Chronic HBV Infection CCR5 RANTES NK Cells
2015/10/12
Background:: CCR5 is a receptor for CCL3 (MIP-1 α), CCL4 (MIP-1 α) and CCL5 (regulated on activation normal T cell expressed and secreted (RANTES)) and play important roles in recruitment of NK cells ...
Effect of Breastfeeding on Serum Osteoprotegerin and Soluble Receptor Activator of Nuclear Factor-Kappa B Ligand in Full Term Neonates
Breast Feeding Infant Formula Osteoprotegerin sRANKL Tumor Necrosis Factor-Alpha (TNFα)
2015/10/9
Background: Human breast milk, the sole source of nutrition during the early neonatal period, is rich in nutrients, hormones, growth factors, and immunoactive molecules, which influence the growth, de...
Expression and Function of the Inducible Costimulator Ligand B7-H2 in Human Airway Smooth Muscle Cells
airway inflammation airway smooth muscle cells B7-H2 DNA synthesis inducible costimulator
2010/11/16
The data demonstrate that ASM cells express functionally active B7-H2, CD40 and OX40L and suggest that B7-H2-dependent signaling may play an active role in a proliferative response rather than in cyto...
目的:构建含人CD40 ligand(CD40L)基因的真核表达载体,并使之在人肝癌细胞HepG2中表达,研究CD40L稳定表达对HepG2细胞的影响.方法:从人外周血单个核细胞总RNA中经RT-PCR扩增出人CD40L基因,经过酶切连接进入真核表达载体pcDNATM3.1/myc-His(-)A制备重组质粒.重组质粒经酶切及测序证实人CD40L基因成功克隆进入真核表达载体pcDNATM3.1/m...
Current status of tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) targeting cancer therapy
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) TRAIL receptor 1 (TRAIL-R1), TRAIL receptor 2 (TRAIL-R2) apoptosis KM mouseTM monoclonal antibody targeting therapeutics
2009/7/15
Monoclonal antibodies have already established a secure position as a very promising strategy for anti-tumor therapeutics. High specificity and high affinity are attractive characteristics of antibodi...
Osteoprotegerin and Ligand of Receptor Activator of Nuclear Factor
Tooth movement RANKL OPG Ovariectomy Periodontal ligament
2010/3/5
Objective: To test the null hypothesis that increased tooth displacement in ovariectomized rats is not related to differential expressions of OPG and RANKL in the periodontium.
Materials and Method...
Expression of c-KIT and its ligand, stem cell factor, in normal and subfertile human testicular tissue
Germ cells proto-oncogenes testis stem cells
2009/2/16
The c-KIT proto-oncogene encodes for a transmembrane receptor and is associated with maturation of several cell types, including germ cells. The ligand of the receptor has been identified as stem ...
Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes
Spermatocyte spermatid acrosome maturation arrest
2008/12/29
It has already been demonstrated that the Notch signaling system is essential for gametogenesis in the adult germ line of Caenorhabditis elegans. However, the role of the Notch signaling system in m...
Identification and regulation of receptor tyrosine kinases Rse and Mer and their ligand Gas6 in testicular somatic cells
Identification regulation receptor tyrosine kinases Mer Gas6 testicular somatic cells
2008/12/25
Receptor tyrosine kinases act to convey extracellular signals to intracellular signaling pathways and ultimately control cell proliferation and differentiation. Rse, Axl, and Mer belong to a newly i...
Receptor Isoform and Ligand-Specific Modulation of Dihydrotestosterone-Induced Prostate Specific Antigen Gene Expression and Prostate Tumor Cell Growth by Estrogens
Androgen receptor androgens estrogen receptor
2008/12/23
Androgens via the androgen receptor (AR) play crucial roles in prostate physiology and pathophysiology. These androgen actions can be either inhibited or potentiated by estrogens. The mechanisms of ...
Genetic Analysis of Kit Ligand Functions During Mouse Spermatogenesis
Genetic Analysis Kit Ligand Functions Mouse Spermatogenesis
2008/12/22
Kit ligand (KITL), also known as mast cell growth factor (MGF), stem cell factor (SCF), and Steel factor,1 and its receptor, KIT, are essential for embryonic and postnatal development of both male and...
Progesterone Receptor Availability in Mouse Spermatozoa During Epididymal Transit and Capacitation：Ligand Blot Detection of Progesterone-Binding Protein
Acrosome reaction sperm maturation
2008/12/19
The goals of the present study were to determine the availability of progesterone (P4) receptor (P4r) in mouse sperm during maturation and capacitation and to make the first steps toward a character...
Progesterone Receptor Availability in Mouse Spermatozoa During Epididymal Transit and Capacitation：Ligand Blot Detection of Progesterone-Binding Protein
Acrosome reaction sperm maturation
2008/12/19
The goals of the present study were to determine the availability of progesterone (P4) receptor (P4r) in mouse sperm during maturation and capacitation and to make the first steps toward a character...
该项目研究系现代医学新型治疗学-基因治疗研究范畴。主要技术内容包括目的基因的克隆，基因表达载体的构建，目的基因表达株的建立，表达株体外细胞生物学特性的研究，基因表达产物的生物学活性检测，移瘤动物的建立，体内抗肿瘤效果的观察。研究内容涉及肿瘤治疗学、分子生物学、细胞生物学、免疫学等相关学科。其主要特点通过让肿瘤细胞表达药物敏感基因TK(又称自杀基因)和抗原呈递细胞-树突状细胞激活基因FL，使抗肿瘤药...
专著信息
书名
Pharmacokinetics of 125I-tumor necrosis factor-related apoptosis inducing ligand in rats.
语种
英文
撰写或编译
作者
Qian Jun,Liu Xiao,Zhu Jianhua,Li Duan,Wang Lianghua,Zhou Jingsong
第一作者单位
出版社
中国临床药学杂志,2...