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Effect of Biochanin A on Serum Visfatin Level of Streptozocin-Induced Diabetic Rats
Visfatin Biochanin A Diabetic Rats
2015/10/14
Background: Bioflavonoids are well known for their multi directional biologic activity including antidiabetic effect. It has been demonstrated that flavonoids can act as insulin secretagogue or insuli...
Variation in the visfatin gene may alter the required dosage of oral antidiabetic agents in type 2 diabetic patients
Visfatin Genotype Antidiabetic agents HOMA QUICKI Type 2 diabetes
2009/11/24
Background: Treatment of diabetes with oral antidiabetic agents is accompanied by considerable variability in pharmacokinetics and clinical efficacy. Genetic factors may contribute to individual diffe...
Visfatin是新发现的由内脏脂肪细胞分泌的一种脂肪细胞因子，可结合并激活胰岛素受体的非胰岛素结合部位，激活胰岛素受体信号通路，从而模拟胰岛素作用，降低机体血糖。这一因子还能够促进脂肪组织的分化、合成及积累。Visfatin cDNA序列与前B细胞克隆增强因子（PBEF）相同，Visfatin在细胞内尚发挥尼克酰胺磷酸核糖转移酶(Nampt)的作用，通过调节氧化型辅酶I（NAD）的生成从而调控S...