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Aging Exacerbates Restraint Stress-Induced Inhibition of Antigen-Specific Antibody Production in Mice
aged mouse immunosuppression phospholipase A2 restraint stress specific antibody
2010/11/16
Background: We have recently found that exposure to acute restraint stress suppresses antigen-specific antibody production, including IgE, in a murine model of allergic rhinitis. Although age-related ...
Inhalation and Incubation with Procaterol Increases Diaphragm Muscle Contractility in Mice
COPD diaphragm muscle endotoxin respiratory muscle fatigue β2-agonists
2010/11/18
Background: Although procaterol is used clinically as a β2-adrenergic receptor agonist to relax airway smooth muscle, it has not yet been clarified whether procaterol has inotropic effects on respirat...
PAR-2 Deficient CD4+ T Cells Exhibit Downregulation of IL-4 and Upregulation of IFN-γ after Antigen Challenge in Mice
CD4+ T cell GATA-3 JNK1 PAR-2 T-bet
2010/11/19
Background: To investigate the functional role of protease activated receptor (PAR) -2 in T lymphocytes, we analyzed TCR-mediated inflammatory cytokine production using PAR-2 deficient (KO) and wild t...
Effects of ultraviolet-inactivated herpes simplex virus type I on atopic dermatitis-like lesions in NC/Nga mice: Role of the suppressor of cytokine signaling in the skin
atopic dermatitis herpes simplex virus suppressor of cytokine signaling (SOCS) Th1 Th2
2010/11/22
Ultraviolet-inactivated HSV treatment would appear to induce a Th1 cellular response and downregulate that of the Th2 pathway in AD-like lesions of NC/Nga mice by bringing about a reduction of SOCS3 e...