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Induction of IgE synthesis by genetically modified CD8+ T cells of a patient with adenosine deaminase deficiency
CD40 ligand CD8+ T cells gene therapy IgE production interleukin-4
2010/11/26
We have previously reported that an adenosine deaminase (ADA)-deficient patient treated with T cell-directed gene therapy had an increase in serum IgE levels, despite a marked inversion of the CD4/CD8...