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Diurnal Variation of Methotrexate Pharmacokinetics in Adults With Osteosarcoma
Methotrexate diurnal variation Osteosarcoma
2009/7/2
The daytime and nighttime dispositions of high dose (12 g/m 2 ) methotrexate were examined in 8 osteosarcoma patients. The plasma and renal clearances, urine pH values and area under the curves were c...