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Dissecting the expression landscape of RNA-binding proteins in human cancers
RNA-binding proteins cancer pathogenesis
2015/3/5
Background RNA-binding proteins (RBPs) play important roles in cellular homeostasis by controlling gene expression at the post-transcriptional level. Results We explore the expression of more than 800...
Molecular Analyses of Early-Onset Gastric Cancer in Brazilian Patients: TP53 Mutations, Cadherin-Catenin and Mucins Proteins Expression
Early-Onset Gastric Cancer Young Patients Cellular Adhesion TP53 Mutations
2013/1/29
Early gastric carcinomas may develop with a molecular profile differing from sporadic carcinomas occurring at a later age. In this study, we analyzed a retrospective series of 88 patients with gastric...
Favorable and unfavorable amino acid residues in water-soluble and transmembrane proteins
Amino Acid Composition Nucleotide Composition Favorable and Unfavorable Residues Water-Soluble and Transmembrane Proteins Thermophilic and Mesophilic Species
2013/1/28
We analyzed the amino acid residues present in the water-soluble and transmembrane proteins of 6 thermophilic and 6 mesophilic species of the domains Archaea and Eubacteria, and characterized them as ...
Dispersal of Golgi matrix proteins during mitotic Golgi disassembly
Golgi apparatus Biogenesis Golgin GRASP
2009/12/23
During mitosis, the mammalian Golgi disassembles into
numerous vesicles and larger membrane structures
referred to as clusters or remnants. Following mitosis, the
vesicles and clusters reassemble t...
Location proteomics - Building subcellular location trees from high resolution 3D fluorescence microscope images of randomly-tagged proteins
Location proteomics 3D fluorescence microscope images
2009/12/23
The overall object of proteomics is to characterize all of the proteins expressed in a given cell type. With the rapiddevelopment of random gene tagging technology and high resolution fluorescence mic...
Research, part funded by the Medical Research Council, has found that a crafty family of ‘limpet-like’ proteins can play a crucial role in repairing DNA damage – according to two research papers publi...
Bioinformatic Analysis of Functional Proteins Involved in Obesity Associated with Diabetes
bioinformatics resistin obesity and type two diabetes
2009/4/29
The twin epidemic of diabetes and obesity pose daunting challenges worldwide. The dramatic rise in obesity-associated diabetes resulted in an alarming increase in the incidence and prevalence of obesi...
Genetic Studies of Bone Diseases: Evidence for Involvement of DNA Damage Response Proteins in Bone Remodeling
p53 Atm c-Abl osterix osteoblast osteoporosis
2009/4/20
Bone remodeling is carried out by bone marrow mesenchymal stem cell derived osteoblasts, which form the bones, and hematopoeitic stem cell derived osteoclasts, which absorb the bones. Their actions a...
Identification of copper-binding nuclear proteins in mouse brain: its involvement in retinoic acid receptor signaling
copper-binding nuclear proteins mouse brain retinoic acid receptor signaling
2009/4/1
Copper is an essential micronutrient with numerous cellular functions. Previous studies have demonstrated that copper deficiency in P19 embryonal carcinoma cells by using a copper depletor, bathocupro...
Copper Binding of Nuclear RNA- and DNA-Binding Proteins p54nrb/NonO and PSF
copper p54nrb/Non-POU-domain-containing octamer binding protein (p54nrb/NonO) polypyrimidine tract-binding protein-associated splicing factor (PSF) nucleus
2009/3/23
The biological function of nuclear copper in mammalian cells is poorly understood because little is known about specific binding protein(s) for nuclear copper. We recently purified that p54nrb/Non-POU...
Induction of Heat Shock Proteins and Mucosal Protection by ZincDerivatives in the Gastrointestinal Mucosa
Induction Heat Shock Proteins Mucosal Protection ZincDerivatives Gastrointestinal Mucosa
2009/3/16
Induction of Heat Shock Proteins and Mucosal Protection by ZincDerivatives in the Gastrointestinal Mucosa.
Periodontal regeneration in intrabony defects after application of enamel matrix proteins with guided tissue regeneration：An experimental study in dogs
Periodontal regeneration enamel matrix proteins guided tissue regeneration
2009/3/2
The aim of this study was to evaluate the effects of enamel matrix proteins (EMP) at the early stage of wound healing in the periodontal tissues by a combination treatment with guided tissue regener...
Effects of stretching stress on the muscle contraction proteins of skeletal muscle myoblasts
stretching stress muscle contraction proteins skeletal muscle myoblasts
2009/3/2
Several studies have reported that growth and differentiation of cultured myoblasts can be facilitated by applying appropriate mechanical stimulus. However, the effects of mechanical stimulus on the c...
Circadian expression of 86- and 84-kDa heat shock proteins in the mouse suprachiasmatic nucleus
Circadian expression 86- and 84-kDa heat shock proteins mouse suprachiasmatic nucleus
2009/3/2
Circadian rhythm pervades in many aspects of the biological processes including basic cellular functions. Here we examined the circadian gene expression of two forms of 90 kDa heat shock proteins re...
Effects of Proteins from Culture Medium on Surface Property of Silanes- Functionalized Magnetic Nanoparticles
Magnetic nanoparticles Culture medium Protein Surface property Cellular uptake
2010/7/16
Monodisperse magnetic nanoparticles (MNPs) were synthesized by thermal decomposition of iron-oleate and functionalized with silanes bearing various functional groups such as amino group (NH2), short-c...