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Structural Basis for the Inhibition of SARS-CoV-2 Main Protease by Antineoplastic Drug Carmofur
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
2020/6/11
The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (Mpro). Here, the X-ray crystal structure of Mpro in complex with carmofur reveals that the carbonyl reactive group of...
The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro
The anti-influenza virus drug arbidol efficient inhibitor SARS-CoV-2 in vitro
2020/6/11
Since December 2019, a novel disease COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread to over 200 countries and infected over 1.50 million people includin...
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Structure-based design antiviral drug candidates targeting SARS-CoV-2 protease
2020/6/12
SARS-CoV-2 is the etiological agent responsible for the global COVID-19 outbreak. The main protease (Mpro) of SARS-CoV-2 is a key enzyme that plays a pivotal role in mediating viral replication and tr...
Short-term effects of a progestational contraceptive drug on food intake, resting energy expenditure, and body weight in young women
menstrual cycle depot medroxyprogesterone acetate contraception
2016/6/12
Studies showed that hormonal fluctuations that
occur over the human menstrual cycle affect energy intake and
expenditure. However, little is known about the possible effects
on body weight regulati...
Dietary supplements, used widely by Americans, are regulated
by the Dietary Supplement Health and Education Act of 1994
(1), an amendment to the Federal Food, Drug and Cosmetic Act.
The Dietary Sup...
A Meta-Analysis of Randomized Clinical Trials Comparing Shorter (Less or Equal Than 6 Months) and Longer (More or Equal Than 12 Months) Dual Anti-Platelet Therapy Following Drug-Eluting Coronary Stents
Drug-Eluting Stents Dual Antiplatelet Therapy Meta-Analysis
2015/11/9
Context: The optimal duration of dual anti-platelet therapy (DAPT) after the implantation of drug-eluting coronary stents (DES) is still the subject of ongoing debate. This meta-analysis was performed...
A Fifty-year challenge in managing drug addiction in Malaysia
Fifty-year challenge drug addiction Malaysia
2015/7/28
The history of substance abuse in Malaysia can be divided into pre- and post-independent era. In pre-independence, the main drug of abuse was opium which was initially consumed by immigrants from Chin...
Sphingosomes a novel approach to vesicular drug delivery
sphingosomes drug delivery sphingomyelin vesicular system
2015/7/21
Vesicular systems have been realized as extremely useful carrier systems in various scientific domains. Sphingosomes is bilayered vesicles in which an aqueous volume is entirely enclosed by membrane l...
Teaching of Critical Analysis of Drug Advertisements to Medical Students
Critical appraisal Drug advertisements WHO criteria
2015/7/21
Background: Medical practitioners utilize drug promotional materials from pharmaceutical companies as a major source of information especially in developing countries. These promotional materials can ...
Comparison of the Knowledge in Core Policies of Essential Drug List Among Medical Practitioners and Medical Students in Galle, Sri Lanka
Rational use of medicine Essential drug list Core policies Medical practitioners Medical students
2015/7/15
Selection of the best and safest medicine should be one of the national economic policies in a country for good health care services. Introduction of detailed module in rational use of medicine (RUM) ...
Mining Biomedical Literature to Extract Pharmacokinetic Drug-Drug Interactions
Machine Learning Pharmacokinetics Information Extraction
2015/5/26
Polypharmacy is a general clinical practice, there is a high chance that multiple administered drugs will interfere with each other, such phenomenon is called drug-drug interaction (DDI). DDI occurs w...
Pharmacodynamics miner : an automated extraction of pharmacodynamic drug interactions
Pharmacodynamics Hrishikesh Lokhande
2015/5/26
Pharmacodynamics (PD) studies the relationship between drug concentration and drug effect on target sites. This field has recently gained attention as studies involving PD Drug-Drug interactions (DDI)...
Design and Implementation of a Laboratory-Based Drug Design and Synthesis Advanced Pharmacy Practice Experience
APPE research drug design synthesis medicinal chemistry
2018/8/17
Objective. To provide students with an opportunity to participate in medicinal chemistry research within the doctor of pharmacy (PharmD) curriculum.
Design. We designed and implemented a 3-course seq...
Dehydron as a Marker For Drug Design
protein function protein dehydron drug design selectivity
2015/1/9
The approach of exploiting highly conserved protein folds and structure in understanding protein function and in designing drugs leads to drugs that are less selective due to association with similar ...
Lack of EGF receptor contributes to drug sensitivity of human germline cells
DNA damage epidermal growth factor receptor drug resistance
2014/12/12
Germline mutations have been associated with generation of various types of tumour. In this study, we investigated genetic alteration of germline tumours that affect the drug sensitivity of cells. Alt...