搜索结果: 1-12 共查到“知识库 circulation”相关记录12条 . 查询时间(0.062 秒)
近日，解放军总医院第六医学中心心血管病医学部陈韵岱教授线上参加第72届美国心脏病学会(ACC)年会暨世界心脏病学大会(WCC)最新临床试验/特色临床研究单元（LBCT/FCR）公布了TARGET（现场部署CT-FFR策略对稳定型冠心病患者的治疗管理研究）临床试验的主要研究结果。研究结果同步发表于国际顶级心血管病期刊《Circulation》杂志（JCR1区TOP期刊，影响因子39.9），陈韵岱教授...
Circulation Research | 周菁课题组与合作者发现基质刚度通过盘状结构域受体1（DDR1）的“液-液”相分离机制抑制Hippo通路（图）
高血压 糖尿病 高脂血症
2023/8/11
动脉硬化在慢性肾病患者中普遍存在，其发生率和严重程度与心血管危险因素密切相关，包括年龄、高血压、糖尿病和高脂血症等。细胞外基质（ECM）刚度可影响血管平滑肌细胞（VSMCs）的表型和行为。ECM硬化会导致VSMC过度增殖、迁移，并从收缩表型向合成表型转化。然而，细胞是如何感知ECM刚度的改变，并将力学信号转化成生物学信号，这一问题仍有待深入研究。
2022年11年10日，北京大学基础医学院生理学与病理生理学系孔炜教授与孙金鹏教授合作在国际知名心血管杂志《Circulation Research》上在线发表了题为“Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification”的研究论文，揭示了细胞外基质蛋白Nidogen-2作为LGR4的一种新...
心力衰竭是各种心脏疾病的终末阶段，是目前危害人类健康的重大公共卫生问题，尽管规范化的药物治疗显著改善心衰的临床症状，但其主要心血管事件如心衰再住院、心血管死亡发生率仍居高不下。因此，深入探索心力衰竭发生发展的病理生理过程和具体机制，有助于改善心衰患者的心功能和远期预后。研究表明，能量代谢对正常心功能的维持至关重要，而心肌能量受损与心力衰竭的发生发展密切相关。因此，深入挖掘心肌能量代谢的调节因子对心...
Intercoronary Continuity: A Rare Variant of Coronary Circulation
Intercoronary continuity Collaterals Angiography
2015/7/10
Coronary circulation if significantly diseased usually develop collaterals between the distal portion of the diseased vessel and the normal artery to accomplish flow in vessel distal to the diseased s...
“类夸克”钙释放：北京大学分子医学研究所再次发表《Circulation Research》封面文章（图）
类夸克；钙释放；北京大学 分子医学研究所 Circulation Research 封面文章
2012/2/9
北京大学分子医学研究所与美国马里兰大学生物技术研究所合作，在钙信号研究中取得重要进展,首次在心脏细胞中证实了“类夸克”钙释放（quarky calcium release）现象。研究论文作为封面故事刊登于今年1月21日出版的《Circulation Research》，同期配发的Macquaide和Sipido文章对此项研究进行了全面评价。
Coupling pediatric ventricle assist devices to the Fontan circulation:simulations with a lumped-parameter model
pediatric ventricle assist devices Fontan circulation simulations lumped-parameter model
2009/12/23
Simulations with a Lumped-Parameter Model In pediatric ventricular assist device (VAD) design, the process of matching device characteristics and dimensions to the relevant disease conditions poses a ...
Pulsatile In Vitro Simulation of the Pediatric Univentricular Circulation for Evaluation of Cardiopulmonary Assist Scenarios
Vitro Simulation Pediatric Univentricular Circulation Cardiopulmonary Assist Scenarios
2009/12/23
The characteristic depressed hemodynamic state and gradually declining circulatory function in Fontan patients necessitates alternative postoperative management strategies incorporating a system level...
Vascular pressures and passage of gas emboli through the pulmonary circulation
pulmonary air animal dog
2009/7/10
Anesthetized dogs received venous air infusions at 0.35 ml.kg-1.min-1. In 60% of a group of 15 dogs, venous bubbles spilled over into the arterial circulation and were detected with the ultrasound Dop...
Antioxidant Status,Lipid Peroxidation Products and Cystatin C as Potential Clinical Markers of Alzheimer's Disease in Systemic Circulation
Alzheimer's disease serum oxidative stress marker Cystatin C
2009/6/29
Growing data suggest oxidative stress contributes to the pathogenesis of Alzheimer's disease (AD). The objective of this study was to assess the value of antioxidant potential (AOP), antioxidant statu...
Antioxidant Effect of Melatonin in Systemic Circulation of Rats After Unilateral Testicular Torsion
Testis torsion melatonin treatment
2009/6/16
Aim: To investigate the antioxidant effects of melatonin in the systemic circulation of rats after unilateral testicular torsion. Materials and Methods: After the approval of the study by the Local Et...
Red wine consumption increases antioxidant status and decreases oxidative stress in the circulation of both young and old humans
decreases oxidative antioxidant status
2008/4/23
Red wine contains a naturally rich source of antioxidants, which may protect the body from oxidative stress, a determinant of age-related disease. The current study set out to determine the in vivo ef...