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Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture
Novel coronavirus alkaloid broad-spectrum antiviral 2019-nCoV SARS-CoV-2
2020/6/11
The emerging SARS-CoV-2 infection associated with the outbreak of viral pneumonia in China is ongoing worldwide. There are no approved antiviral therapies to treat this viral disease. Here we examined...
Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019
coronavirus disease-19 (COVID-19) RNAemia IL-6 critically ill patients cytokine storm
2020/6/12
Although the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load in respiratory specimens has been widely used to diagnose coronavirus disease 2019 (COVID-19), it is u...
Rapid and visual detection of 2019 novel coronavirus (SARS-CoV-2) by a reverse transcription loop-mediated isothermal amplification assay
SARS-CoV-2 RT-LAMP COVID-19 Detection Visual
2020/6/12
To evaluate a reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and compare it with RT-PCR.
Inhibition of SARS-CoV-2 (Previously 2019-nCoV) Infection by a Highly Potent Pan-Coronavirus Fusion Inhibitor Targeting Its Spike Protein That Harbors a High Capacity to Mediate Membrane Fusion
Inhibition SARS-CoV-2 Pan-Coronavirus Fusion Inhibitor Targeting High Capacity Mediate Membrane Fusion
2020/6/12
The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health. To develop specific anti-coronavirus therapeuti...
An outbreak of unusual respiratory disease, initially dominated by pneumonia, in Wuhan, China, is caused by infection by a novel coronavirus.The new virus was initially named 2019-nCoV by WHO.1–3
Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
2019-nCoV SARS-CoV ACE2 monoclonal antibody RBD
2020/6/12
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health. Currently, how...
The First Disease X is Caused by a Highly Transmissible Acute Respiratory Syndrome Coronavirus
Coronavirus 2019-nCoV SARS-CoV Pneumonia Acute respiratory syndrome Disease X
2020/6/12
Based on the announcement of the World Health Organization (WHO) in 2018, the Wuhan pneumonia caused by an unknown etiology should be recognized as the first Disease X. Later, the pathogen was identif...
Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
Remdesivir chloroquine effectively inhibit novel coronavirus (2019-nCoV) vitro
2020/6/12
In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China. The initial cases were linked to exposures in a seafood mark...
A pneumonia outbreak associated with a new coronavirus of probable bat origin
pneumonia outbreak associated new coronavirus probable bat origin
2020/6/12
Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1,2,3,4...
An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies
emerging coronaviru pneumonia outbreak Wuhan China: calling developing therapeutic prophylactic strategies
2020/6/12
In December of 2019, an outbreak of pneumonia caused by an unknown aetiology occurred in Wuhan, China and most patients were linked to a single seafood market, which reportedly sold seafood and some l...
Prevalence of canine coronavirus and parvovirus infections in dogs with gastroenteritis in Thailand
canine coronavirus canine parvovirus type 2 gastroenteritis PC
2015/1/28
Canine coronavirus (CCV) and canine parvovirus type 2 (CPV-2) are the causative agents of gastroenteritis in dogs. Seventy fecal samples from dogs with signs of gastroenteritis (vomiting and diarrhea)...
Monoclonal antibodies to bovine coronavirus and their use in enzymoimmunoanalysis and immunochromatography
Immunochromatographic test (ICT) ELISA
2015/1/20
Two monoclonal antibodies (MAb) to the outer structural protein E2 (spike peplomeric protein) and two MAb to the inner capsid protein N of bovine coronavirus (BCV) were prepared and identified by West...
Altered pathogenicity, immunogenicity, tissue tropism and 3'-7 kb region sequence of an avian infectious bronchitis coronavirus strain after serial passage in embryos
vian infectious bronchitis coronavirus Pathogenicity Immunogenicity Tissue tropism Genome sequence Serial passage
2016/12/20
In this study, we attenuated a Chinese LX4-type nephropathogenic infectious bronchitis virus (IBV) strain, CK/CH/LHLJ/04V, by serial passage in embryonated chicken eggs. Based on sequence analysis of ...