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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Structure-based design antiviral drug candidates targeting SARS-CoV-2 protease
2020/6/12
SARS-CoV-2 is the etiological agent responsible for the global COVID-19 outbreak. The main protease (Mpro) of SARS-CoV-2 is a key enzyme that plays a pivotal role in mediating viral replication and tr...
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
Structure Mpro SARS-CoV-2 discovery inhibitors
2020/6/12
A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the aetiological agent responsible for the 2019–2020 viral pneumonia outbreak of coronavirus disease 2019 (...
Linkage Disequilibrium and Haplotype Block Structure in Portuguese Holstein Cattle
single nucleotide polymorphism GWAS dairy cattle
2018/3/5
The objectives of this study were to estimate linkage disequilibrium (LD), describe and scan a haplotype block for
the presence of genes that may affect milk production traits in Portuguese Holstein ...
Effect of Glutamine and/or Probiotic (Enterococcus faecium) Feed Supplementation on Piglet Performance, Intestines Structure, and Antibacterial Activity
piglet feeding microbial probiotic intestinal microbiota intestine morphology
2018/3/5
The effect of glutamine and/or probiotic (Enterococcus feacium) supplements on piglet performance, intestines
structure, and microbial status was estimated on 181 piglets (16 litters) of Polish Landr...
ACCURACY ESTIMATION OF THE OPTICAL FLOWMETHODS IN THE IRIS STRUCTURE MOTION ANALYSIS VIA CONTROLLED DEFORMATIONS
Biometrics Iris Structure Computer Vision Image Analysis Optical Flow Horn-Schunck Method Lucas-Kanade Method Accuracy Estimation
2017/6/19
The iris structure motion is analyzed. Extension and compression of the iris structural elements are nonlinear with respect to the pupil radius change. To reveal this nonlinearity the Lucas-Kanade, Ho...
Vascular Function and Structure in Veteran Athletes after Myocardial Infarction
PHYSICAL ACTIVITY ENDOTHELIAL FUNCTION CARDIOVASCULAR RISK SECONDARY PREVENTION LIFELONG EXERCISE TRAINING
2018/4/24
Purpose Although athletes demonstrate lower cardiovascular risk and superior vascular function compared with sedentary peers, they are not exempted from cardiac events (i.e., myocardial infarction [MI...
Effects of γ-aminobutyric acid on the thymus tissue structure,antioxidant activity,cell apoptosis,and cytokine levels in chicks under heat stress
heat shock GABA chick thymus immune function development
2016/12/20
This study aims to investigate the effect of dietary γ-aminobutyric acid (GABA) on the development of thymus tissue structure and function in chicks under heat stress. One-day-old male Wenchang chicks...
Mediterranean diet score and left ventricular structure and function: the Multi-Ethnic Study of Atherosclerosis
cardiovascular disease epidemiology Mediterranean diet pattern left ventricular structure left ventricular function subclinical cardiovascular
2018/12/13
Background: Data are limited on the relation between dietary patterns and left ventricular (LV) structure and function.
Eggshell structure,measurements,and quality-affecting factors in laying hens:a review
eggshell composition eggshell quality oviposition time genotype housing system
2016/8/1
Eggshell quality is one of the most significant factors affecting poultry industry; it economically influences egg production and hatchability. Eggshell consists of shell membranes and the true shell ...
Data Structure Fusion
Data Structure
2016/5/24
We consider the problem of specifying data structures with complex sharing in a manner that is both declarative and results in provably correct code. In our approach, abstract data types are speci-fie...
Structure Slicing: Extending Logical Regions with Fields
Structure Slicing Extending Logical Regions Fields
2016/5/24
Applications on modern supercomputers are increasingly limited by the cost of data movement, but mainstream programming systems have few abstractions for describing the structure of a program’s data. ...
Effects of Three Feeding Systems on Production Performance, Rumen Fermentation and Rumen Digesta Particle Structure of Beef Cattle
Production Performance Rumen Fermentation Rumen Digesta Particle
2016/5/20
The effects of three different feeding systems on beef cattle production performance, rumen fermentation, and rumen digesta particle structure were investigated by using 18 Limousin (steers) with a si...
Neurovascular Control and Cardiac Structure in Amateur Runners with Hypertension
BAROREFLEX SENSITIVITY ARTERIAL STIFFNESS SYMPATHETIC NERVOUS SYSTEM
2017/4/13
Purpose: The neurovascular mechanisms underlying hypertension are minimized by exercise training. However, it is not known whether previously trained individuals with hypertension would have deleterio...
Constructing Structure Ensembles of Intrinsically Disordered Proteins from Chemical Shift Data
Constructing Structure Ensembles Intrinsically Disordered Proteins Chemical Shift Data
2016/1/22
Modeling the structural ensemble of intrinsically disordered proteins (IDPs),which lack fixed structures, is essential in understanding their cellular functions and re-vealingtheirregulationmechanisms...
A Study and Experiment on Spatial Statistical CharacterIStic to Discover River Structure knowledge
Spatial Statistics Data Mining River Structure Classification
2015/12/2
River structure is a direct concept for the distribution of rivers in nature. In spatial database, river structure is a type of spatial relations composed by river features. This paper proposes the ch...