搜索结果: 1-15 共查到“知识库 医学 targeted”相关记录17条 . 查询时间(0.062 秒)
Signal Transduction and Targeted Therapy丨柳素玲团队等发现趋化因子CCL20通过重塑肿瘤免疫微环境促进乳腺癌进展的新机制（图）
乳腺癌 肿瘤干细胞 肿瘤恶性 生物医学研究院
2023/4/13
肿瘤微环境（tumor microenvironment，TME）在肿瘤恶性和治疗抵抗中发挥着重要作用。近年来，根据TME特点挖掘潜在靶点并开发安全有效的免疫疗法逐渐成为乳腺癌治疗的研究热点。2018年7月27日，复旦大学生物医学研究院/附属肿瘤医院柳素玲团队在PLOS Biology杂志在线发表了题为CCL20 triggered by chemotherapy hinders the ther...
A targeted goal for energy-restricted diets in the management of coronary risk?
blood lipids CAD risk
2016/6/12
Over the past decade, the independent contribution of elevated
body weight to the development of coronary artery disease
(CAD) has been elucidated (1). Treatment of blood lipids in
overweight indiv...
Inhibition of Ape1's DNA Repair Activity as a Target in Cancer: Identification of Novel Small Molecules that have Translational Potential for Molecularly Targeted Cancer Therapy
Cancer Chemotherapy Base Excision Repair DNA Repair
2015/5/25
The DNA Base Excision Repair (BER) pathway repairs DNA damaged by endogenous and exogenous agents including chemotherapeutic agents. Removal of the damaged base by a DNA glycosylase creates an apurini...
Targeted therapies, aspects of pharmaceutical and oncological management
Targeted therapies oncological management
2015/4/8
A revolution is underway in cancer therapy and care. Now, based on identifying in a patient’s cancer those genetic
alterations that drive cancer growth, use of cancer therapy is more targeted and ca...
Australian perspective on the role of targeted therapies in gastroesophageal cancer
Australian targeted therapies gastroesophageal cancer
2015/4/2
Oesophagogastric cancers are the fourth highest cause of cancer related deaths worldwide and the sixth most common cause of cancer related deaths in the Australian population. Their incidence has been...
Epithelial ovarian cancer is a challenging disease to treat, with the majority of patients presenting with advanced disease. Despite aggressive surgical debulking and platinum-based chemotherapy, many...
Targeted therapies in haematological malignancies
Targeted therapies haematological malignancies
2015/3/26
By delivering major improvements in patient outcomes, targeted therapies have revolutionised treatment paradigms for many haematological malignancies, particularly chronic myeloid leukaemia, acute pro...
Search for the Holy Grail: evolving targeted therapies in breast cancer
breast cancer endocrine therapy
2015/3/26
Understanding growth factor pathways overactive in subsets of women with breast cancer has enabled the development of agents which target these more precisely, enhancing efficacy of standard therapies...
The landscape of treatment for renal cell carcinoma has changed radically over the last few years. Previously, the most effective treatments were too toxic, too expensive or too ineffective. Careful b...
Our understanding of the molecular pathways that mediate cancer cell proliferation has increased significantly and with
this comes the rapid development of molecular targeted therapies. The epidermal...
Molecular medicine represents a new approach to therapeutics and has significant implications for the practice of oncology in the future. Leveraging the rapidly increasing pace of technological and sc...
The explosion in knowledge about the molecular and cellular biology of cancer has led to the identification of many molecules or physiological processes that can be therapeutically exploited to treat ...
Altering DNA Base Excision Repair: Use of Nuclear and Mitochondrial-Targeted N-Methylpurine DNA Glycosylase to Sensitize Astroglia to Chemotherapeutic Agents
DNA repair astrocytes
2014/12/12
Primary astrocyte cultures were used to investigate the modulation of DNA repair as a tool for sensitizing astrocytes to genotoxic agents. Base excision repair (BER) is the principal mechanism by whic...
siRNA Targeted to p53 Attenuates Ischemic and Cisplatin-Induced Acute Kidney Injury
acute kidney injury siRNA
2014/12/11
Proximal tubule cells (PTCs), which are the primary site of kidney injury associated with ischemia or nephrotoxicity, are the site of oligonucleotide reabsorption within the kidney. We exploited this ...
Pharmacists' Role in Targeted Cancer Therapy in Australia and Implications for Pharmacy Education
cancer targeted therapy monoclonal antibody genomic medicine pharmacodiagnostics
2018/5/24
Objectives. To investigate the pharmacists' role in providing targeted therapies to patients and its implications for pharmacy education.
Methods. Nine pharmacy faculty members, 12 clinical pharmacis...