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Gene Expression Profiles of BAD and Bcl-xL in the CA1 Region of the Hippocampus Following Global Ischemic/Reperfusion and FK-506 Administration
Ischemic/Reperfusion Real-Time RT-PCR Hippocampus Tacrolimus Bcl-xL Gene BAD
2015/12/29
Background: The hippocampus is a tiny nub in the mammalian brain that is involved in forming, organizing, and storing memories. Global cerebral ischemia (GCI) and reperfusion induced apoptosis lead to...
Single-Nucleotide Polymorphisms Within MicroRNAs Sequences and Their 3' UTR Target Sites May Regulate Gene Expression in Gastrointestinal Tract Cancers
MicroRNAs Gastrointestinal Neoplasms Colorectal Neoplasms Gastric Neoplasms
2015/10/13
Background: Esophageal, stomach, and colorectal cancers are commonly lethal gastrointestinal tract (GIT) neoplasms, causing almost two million deaths worldwide each year. some environmental risk facto...
The Association between Sporadic Alzheimer’s Disease and the Human ABCA1 and APOE Gene Polymorphisms in Iranian Population
Alzheimer’s disease Genetic association Apolipoprotein E Polymorphism ATP-binding cassette transporter A1 Iran
2015/9/23
Background: Apolipoprotein E (APOE), which its ε4 allele has been reported as a risk factor in late onset Alzheimer’s disease (AD), is the main cholesterol carrier in the brain. ATP-binding cassette t...
Molecular genetic,diagnosis,prevention and gene therapy in prostatic cancer: review article
Molecular genetic diagnosis prevention gene therapy prostate cancer
2009/12/15
The prostate is a small gland located below the bladder and upper part of the urethra. In developed countries prostate cancer is the second common cancer (after skin cancer), and also the second leadi...
Collection of multiple processes that increase the chronological age of an organism leading to death is defined as aging, and even though important, it is poorly understood. Recent research has shown ...
Genomic signature and toxicogenomics comparison of polycationic gene delivery nanosystems in human alveolar epithelial A549 cells
Gene Delivery Nanosystem Gene Expression Genocompatibility Microarray Toxicogenomics
2009/12/3
Background and the purpose of the study: Of the gene delivery systems, non-viral polycationic gene delivery nanosystems have been alternatively exploited as a relatively safe delivery reagents compare...
Deletion and Testicular Expression of DAZ (Deleted in Azoospermia) Gene in Patients with Non-Obstructive Azoospermia
Infertility Deleted in Azoospermia Gene Y Chromosome Azoospermia Iran
2009/11/26
Background: Deletions of the DAZ (deleted in azoospermia) genes within the human Y chromosome's AZFc region are the most common cause of spermatogenesis failure. These deletions are usually assessed b...
Characterization of the human GYS2 gene and its product using bioinformatic tools
Glycogen synthase genomics evolution promoter expression
2009/7/6
Aim: The GYS2 gene, which encodes for glycogen synthase 2 (liver) (GS), is an enzyme responsible for the synthesis of 1,4-linked glucose chains in glycogen. The present study aimed to investigate th...
The Use of a Nonradioactive Digoxigenin Labeled Probe for Detection of Apo(a) Gene Size
Lp(a) coronary artery disease dot blot analysis DIG-labeling apo(a) gene
2009/6/30
Elevated lipoprotein(a) [Lp(a)] concentrations are associated with premature coronary heart disease and early myocardial infarction. In the general human population the sizes of apolipoprotein [apo(a)...
Detection of the SRY Gene in a 46,XY Phenotypic Female by the PCR-SSCP Method
PCR-SSCP Sex reversal SRY 46 XY Female
2009/6/30
The short arm of the human Y chromosome determines maleness, initiating the development of the testes. Mutations and deletions in this region affect gonadal differentiation, causing primary sex revers...
IFN-g-Mediated Transcriptional Induction of the IDO (Indolamine 2,3-Dioxygenase) Gene Requires Activity of p68/PKR Protein Kinase
IFN p68/PKR IDO transcription
2009/6/26
We investigated whether the activity of double-stranded RNA activated kinase (p68/PKR) is necessary for induction of IDO (indolamine 2,3 -dioxygenase) gene by IFN-g. For this purpose, we planned to ab...
Detection of Human Cytomegalovirus Gene in Formalin-Fixed Paraffin-Embedded Fetal Tissues
Diagnostic application of the ligation-dependant polymerase chain reaction
2009/6/26
Cytomegalovirus (CMV) is an opportunistic pathogen that can cause infection at any time during the course of a lifetime and constitutes an important cause of intrauterine infection and death in newbor...
Quantification of The FLI1 Gene Expression By Real-Time Quantitative RT-PCR
Gene expression FLI1 PML-RARA Real Time RT-PCR
2009/6/25
In this study, quantification levels were investigated to define alterations in the expression of the FLI1 gene on acute promyelocytic leukemia (APL), which is characterized by a reciprocal t(15,17) t...
Vitamin D Dependent Down Regulation of Arf1 Gene in Human Leukemia Cell Line HL-60
Gene expression ARF1 Vitamin D Real-Time RT-PCR
2009/6/24
ADP-ribosylation factor 1 (ARF1) is a gene belonging to the ARF gene family. ARF genes, small guanine nucleotide-binding proteins, constitute a family of the RAS superfamily. This superfamily function...
Expression of the Tumour Suppressor Gene p53 in Odontogenic Cysts
Odontogenic cysts p53 protein immunohistochemistry
2009/6/24
The protein p53 seems to be related to the suppression of cell proliferation. Positive tissues appear to have a higher proliferative activity than negative tissues. Mutation of the p53 tumour suppres...