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Structural Basis for the Inhibition of SARS-CoV-2 Main Protease by Antineoplastic Drug Carmofur
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
2020/6/11
The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (Mpro). Here, the X-ray crystal structure of Mpro in complex with carmofur reveals that the carbonyl reactive group of...
The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro
The anti-influenza virus drug arbidol efficient inhibitor SARS-CoV-2 in vitro
2020/6/11
Since December 2019, a novel disease COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread to over 200 countries and infected over 1.50 million people includin...
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Structure-based design antiviral drug candidates targeting SARS-CoV-2 protease
2020/6/12
SARS-CoV-2 is the etiological agent responsible for the global COVID-19 outbreak. The main protease (Mpro) of SARS-CoV-2 is a key enzyme that plays a pivotal role in mediating viral replication and tr...
Human herpesvirus infection in drug-induced hypersensitivity syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome
cytomegalovirus drug-induced hypersensitivity syndrome human herpesvirus-6 Stevens-Johnson syndrome toxic epidermal necrolysis
2010/11/22
Human herpesvirus-6 reactivation in patients with DIHS is not due to non-specific reactivation induced by steroid therapy, but to events specific to DIHS. We hypothesize that DIHS may occur as a resul...